Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact

Vitamin K epoxide reductase (VKOR) drives the vitamin K cycle, activating vitamin K-dependent blood clotting factors. VKOR is also the target of the widely used anticoagulant drug, warfarin. Despite VKOR’s pivotal role in coagulation, its structure and active site remain poorly understood. In additi...

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Detalles Bibliográficos
Autores principales: Chiasson, Melissa A, Rollins, Nathan J, Stephany, Jason J, Sitko, Katherine A, Matreyek, Kenneth A, Verby, Marta, Sun, Song, Roth, Frederick P, DeSloover, Daniel, Marks, Debora S, Rettie, Allan E, Fowler, Douglas M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462613/
https://www.ncbi.nlm.nih.gov/pubmed/32870157
http://dx.doi.org/10.7554/eLife.58026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462613/
https://www.ncbi.nlm.nih.gov/pubmed/32870157
http://dx.doi.org/10.7554/eLife.58026

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