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Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of the role of cetuximab sensitivity and HPV status

BACKGROUND: The epidermal growth factor receptor (EGFR) is overexpressed by 80–90% of squamous cell carcinoma of head and neck (HNSCC). In addition to inhibiting EGFR signal transduction, cetuximab, a monoclonal antibody targeting EGFR can also bind to fragment crystallisable domain of immunoglobuli...

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Detalles Bibliográficos
Autores principales:	Baysal, Hasan, De Pauw, Ines, Zaryouh, Hannah, De Waele, Jorrit, Peeters, Marc, Pauwels, Patrick, Vermorken, Jan Baptist, Smits, Evelien, Lardon, Filip, Jacobs, Julie, Wouters, An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462851/ https://www.ncbi.nlm.nih.gov/pubmed/32541873 http://dx.doi.org/10.1038/s41416-020-0934-3

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