(1)H, (13)C, and (15)N Backbone assignments of the human brain and acute leukemia cytoplasmic (BAALC) protein

The brain and acute leukemia cytoplasmic (BAALC; UniProt entry Q8WXS3) is a 180-residue-long human protein having six known isoforms. BAALC is expressed in either hematopoietic or neuroectodermal cells and its specific function is still to be revealed. However, as a presumably membrane-anchored protein at the cytoplasmic side it is speculated that BAALC exerts its function at the postsynaptic densities of certain neurons and might play a role in developing cytogenetically normal acute myeloid leukemia (CN-AML) when it is highly overexpressed by myeloid or lymphoid progenitor cells. In order to better understand the physiological role of BAALC and to provide the basis for a further molecular characterization of BAALC, we report here the (1)H, (13)C, and (15)N resonance assignments for the backbone nuclei of its longest hematopoietic isoform (isoform 1). In addition, we present a (1)H(N) and (15)N(H) chemical shift comparison of BAALC with its shortest, neuroectodermal isoform (isoform 6) which shows only minor changes in the (1)H and (15)N chemical shifts.