Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma

BACKGROUND: Cytochrome P450 1B1 (CYP1B1) is mostly expressed in tumours and displays unusual properties. Its two polymorphic forms were differently associated with anticancer drug sensitivity. We decipher here the role of this polymorphism in anticancer drug efficacy in vitro, in vivo and in the cli...

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Detalles Bibliográficos
Autores principales: Morvan, Valérie Le, Richard, Élodie, Cadars, Maud, Fessart, Delphine, Broca-Brisson, Léa, Auzanneau, Céline, Pasquies, Alban, Modesto, Anouchka, Lusque, Amélie, Mathoulin-Pélissier, Simone, Lansiaux, Amélie, Robert, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462978/
https://www.ncbi.nlm.nih.gov/pubmed/32565541
http://dx.doi.org/10.1038/s41416-020-0932-5

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