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Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated herita...

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Detalles Bibliográficos
Autores principales: Tiego, Jeggan, Chamberlain, Samuel R., Harrison, Ben J., Dawson, Andrew, Albertella, Lucy, Youssef, George J., Fontenelle, Leonardo F., Yücel, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463011/
https://www.ncbi.nlm.nih.gov/pubmed/32873811
http://dx.doi.org/10.1038/s41598-020-71013-x
Descripción
Sumario:Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A(2) = 0.33), modest additive genetic or common environmental effects for obsessiveness (A(2) = 0.25; C(2) = 0.23), and moderate effects of common environment (C(2) = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.