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Heritability of overlapping impulsivity and compulsivity dimensional phenotypes

Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated herita...

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Autores principales: Tiego, Jeggan, Chamberlain, Samuel R., Harrison, Ben J., Dawson, Andrew, Albertella, Lucy, Youssef, George J., Fontenelle, Leonardo F., Yücel, Murat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463011/
https://www.ncbi.nlm.nih.gov/pubmed/32873811
http://dx.doi.org/10.1038/s41598-020-71013-x
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author Tiego, Jeggan
Chamberlain, Samuel R.
Harrison, Ben J.
Dawson, Andrew
Albertella, Lucy
Youssef, George J.
Fontenelle, Leonardo F.
Yücel, Murat
author_facet Tiego, Jeggan
Chamberlain, Samuel R.
Harrison, Ben J.
Dawson, Andrew
Albertella, Lucy
Youssef, George J.
Fontenelle, Leonardo F.
Yücel, Murat
author_sort Tiego, Jeggan
collection PubMed
description Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A(2) = 0.33), modest additive genetic or common environmental effects for obsessiveness (A(2) = 0.25; C(2) = 0.23), and moderate effects of common environment (C(2) = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.
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spelling pubmed-74630112020-09-03 Heritability of overlapping impulsivity and compulsivity dimensional phenotypes Tiego, Jeggan Chamberlain, Samuel R. Harrison, Ben J. Dawson, Andrew Albertella, Lucy Youssef, George J. Fontenelle, Leonardo F. Yücel, Murat Sci Rep Article Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A(2) = 0.33), modest additive genetic or common environmental effects for obsessiveness (A(2) = 0.25; C(2) = 0.23), and moderate effects of common environment (C(2) = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors. Nature Publishing Group UK 2020-09-01 /pmc/articles/PMC7463011/ /pubmed/32873811 http://dx.doi.org/10.1038/s41598-020-71013-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tiego, Jeggan
Chamberlain, Samuel R.
Harrison, Ben J.
Dawson, Andrew
Albertella, Lucy
Youssef, George J.
Fontenelle, Leonardo F.
Yücel, Murat
Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title_full Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title_fullStr Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title_full_unstemmed Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title_short Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
title_sort heritability of overlapping impulsivity and compulsivity dimensional phenotypes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463011/
https://www.ncbi.nlm.nih.gov/pubmed/32873811
http://dx.doi.org/10.1038/s41598-020-71013-x
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