Quantifying drug tissue biodistribution by integrating high content screening with deep-learning analysis

Quantitatively determining in vivo achievable drug concentrations in targeted organs of animal models and subsequent target engagement confirmation is a challenge to drug discovery and translation due to lack of bioassay technologies that can discriminate drug binding with different mechanisms. We h...

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Detalles Bibliográficos
Autores principales: Li, Zhuyin, Xiao, Youping, Peng, Jia, Locke, Darren, Holmes, Derek, Li, Lei, Hamilton, Shannon, Cook, Erica, Myer, Larnie, Vanderwall, Dana, Cloutier, Normand, Siddiqui, Akbar M., Whitehead, Paul, Bishop, Richard, Zhao, Lei, Cvijic, Mary Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463244/
https://www.ncbi.nlm.nih.gov/pubmed/32873881
http://dx.doi.org/10.1038/s41598-020-71347-6

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