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Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching
Paper-based microfluidic devices are an attractive platform for developing low-cost, point-of-care diagnostic tools. As paper-based devices’ detection chemistries become more complex, more complicated devices are required, often entailing the sequential delivery of different liquids or reagents to r...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463483/ https://www.ncbi.nlm.nih.gov/pubmed/32823829 http://dx.doi.org/10.3390/mi11080773 |
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author | Kalish, Brent Tan, Mick Kyle Tsutsui, Hideaki |
author_facet | Kalish, Brent Tan, Mick Kyle Tsutsui, Hideaki |
author_sort | Kalish, Brent |
collection | PubMed |
description | Paper-based microfluidic devices are an attractive platform for developing low-cost, point-of-care diagnostic tools. As paper-based devices’ detection chemistries become more complex, more complicated devices are required, often entailing the sequential delivery of different liquids or reagents to reaction zones. Most research into flow control has been focused on introducing delays. However, delaying the flow can be problematic due to increased evaporation leading to sample loss. We report the use of a CO(2) laser to uniformly etch the surface of the paper to modify wicking speeds in paper-based microfluidic devices. This technique can produce both wicking speed increases of up to 1.1× faster and decreases of up to 0.9× slower. Wicking speeds can be further enhanced by etching both sides of the paper, resulting in wicking 1.3× faster than unetched channels. Channels with lengthwise laser-etched grooves were also compared to uniformly etched channels, with the most heavily grooved channels wicking 1.9× faster than the fastest double-sided etched channels. Furthermore, sealing both sides of the channel in packing tape results in the most heavily etched channels, single-sided, double-sided, and grooved, wicking over 13× faster than unetched channels. By selectively etching individual channels, different combinations of sequential fluid delivery can be obtained without altering any channel geometry. Laser etching is a simple process that can be integrated into the patterning of the device and requires no additional materials or chemicals, enabling greater flow control for paper-based microfluidic devices. |
format | Online Article Text |
id | pubmed-7463483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74634832020-09-04 Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching Kalish, Brent Tan, Mick Kyle Tsutsui, Hideaki Micromachines (Basel) Article Paper-based microfluidic devices are an attractive platform for developing low-cost, point-of-care diagnostic tools. As paper-based devices’ detection chemistries become more complex, more complicated devices are required, often entailing the sequential delivery of different liquids or reagents to reaction zones. Most research into flow control has been focused on introducing delays. However, delaying the flow can be problematic due to increased evaporation leading to sample loss. We report the use of a CO(2) laser to uniformly etch the surface of the paper to modify wicking speeds in paper-based microfluidic devices. This technique can produce both wicking speed increases of up to 1.1× faster and decreases of up to 0.9× slower. Wicking speeds can be further enhanced by etching both sides of the paper, resulting in wicking 1.3× faster than unetched channels. Channels with lengthwise laser-etched grooves were also compared to uniformly etched channels, with the most heavily grooved channels wicking 1.9× faster than the fastest double-sided etched channels. Furthermore, sealing both sides of the channel in packing tape results in the most heavily etched channels, single-sided, double-sided, and grooved, wicking over 13× faster than unetched channels. By selectively etching individual channels, different combinations of sequential fluid delivery can be obtained without altering any channel geometry. Laser etching is a simple process that can be integrated into the patterning of the device and requires no additional materials or chemicals, enabling greater flow control for paper-based microfluidic devices. MDPI 2020-08-14 /pmc/articles/PMC7463483/ /pubmed/32823829 http://dx.doi.org/10.3390/mi11080773 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kalish, Brent Tan, Mick Kyle Tsutsui, Hideaki Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title | Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title_full | Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title_fullStr | Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title_full_unstemmed | Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title_short | Modifying Wicking Speeds in Paper-Based Microfluidic Devices by Laser-Etching |
title_sort | modifying wicking speeds in paper-based microfluidic devices by laser-etching |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463483/ https://www.ncbi.nlm.nih.gov/pubmed/32823829 http://dx.doi.org/10.3390/mi11080773 |
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