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Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression

Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in human breast cancer. However, the cell type-specific Ctsl functions responsible for this association remain elusive. Methods: Beca...

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Detalles Bibliográficos
Autores principales:	Parigiani, María Alejandra, Ketscher, Anett, Timme, Sylvia, Bronsert, Peter, Schlimpert, Manuel, Kammerer, Bernd, Jacquel, Arnaud, Chaintreuil, Paul, Reinheckel, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463523/ https://www.ncbi.nlm.nih.gov/pubmed/32707827 http://dx.doi.org/10.3390/cancers12082004

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