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Course and Outcome of Erythema Migrans in Pregnant Women
Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990–2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcom...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463612/ https://www.ncbi.nlm.nih.gov/pubmed/32722090 http://dx.doi.org/10.3390/jcm9082364 |
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author | Maraspin, Vera Lusa, Lara Blejec, Tanja Ružić-Sabljić, Eva Pohar Perme, Maja Strle, Franc |
author_facet | Maraspin, Vera Lusa, Lara Blejec, Tanja Ružić-Sabljić, Eva Pohar Perme, Maja Strle, Franc |
author_sort | Maraspin, Vera |
collection | PubMed |
description | Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990–2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies was also evaluated. The pregnant women reported constitutional symptoms less frequently than the non-pregnant women (22.4% vs. 37.2%, p < 0.001). Pregnant women diagnosed with EM later during pregnancy had a lower probability of reporting constitutional symptoms (odds ratio = 0.97 for 1-week difference in gestation week at diagnosis of EM, 95% CI: 0.94–0.99, p = 0.02). The outcome of pregnancy was unfavorable in 42/304 (13.8%) patients: preterm birth in 22/42 (52.4%), fetal/perinatal death in 10/42 (23.8%), and/or anomalies in 15/42 (35.7%). Several patients had potential explanation(s) for the unfavorable outcome. In conclusion, the course of early LB during pregnancy is milder than in age-matched non-pregnant women. The outcome of pregnancy with the treatment approach used in the present study (i.v. ceftriaxone 2 g once daily for 14 days) is favorable. |
format | Online Article Text |
id | pubmed-7463612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74636122020-09-02 Course and Outcome of Erythema Migrans in Pregnant Women Maraspin, Vera Lusa, Lara Blejec, Tanja Ružić-Sabljić, Eva Pohar Perme, Maja Strle, Franc J Clin Med Article Information on Lyme borreliosis (LB) during pregnancy is limited. In the present study, the course and outcome of erythema migrans (EM) in 304 pregnant women, diagnosed in the period 1990–2015, was assessed and compared with that in age-matched non-pregnant women. The frequency of unfavorable outcome of pregnancies was also evaluated. The pregnant women reported constitutional symptoms less frequently than the non-pregnant women (22.4% vs. 37.2%, p < 0.001). Pregnant women diagnosed with EM later during pregnancy had a lower probability of reporting constitutional symptoms (odds ratio = 0.97 for 1-week difference in gestation week at diagnosis of EM, 95% CI: 0.94–0.99, p = 0.02). The outcome of pregnancy was unfavorable in 42/304 (13.8%) patients: preterm birth in 22/42 (52.4%), fetal/perinatal death in 10/42 (23.8%), and/or anomalies in 15/42 (35.7%). Several patients had potential explanation(s) for the unfavorable outcome. In conclusion, the course of early LB during pregnancy is milder than in age-matched non-pregnant women. The outcome of pregnancy with the treatment approach used in the present study (i.v. ceftriaxone 2 g once daily for 14 days) is favorable. MDPI 2020-07-24 /pmc/articles/PMC7463612/ /pubmed/32722090 http://dx.doi.org/10.3390/jcm9082364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maraspin, Vera Lusa, Lara Blejec, Tanja Ružić-Sabljić, Eva Pohar Perme, Maja Strle, Franc Course and Outcome of Erythema Migrans in Pregnant Women |
title | Course and Outcome of Erythema Migrans in Pregnant Women |
title_full | Course and Outcome of Erythema Migrans in Pregnant Women |
title_fullStr | Course and Outcome of Erythema Migrans in Pregnant Women |
title_full_unstemmed | Course and Outcome of Erythema Migrans in Pregnant Women |
title_short | Course and Outcome of Erythema Migrans in Pregnant Women |
title_sort | course and outcome of erythema migrans in pregnant women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463612/ https://www.ncbi.nlm.nih.gov/pubmed/32722090 http://dx.doi.org/10.3390/jcm9082364 |
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