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Lead Compounds in the Context of Extracellular Vesicle Research
Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an im...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463631/ https://www.ncbi.nlm.nih.gov/pubmed/32751565 http://dx.doi.org/10.3390/pharmaceutics12080716 |
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author | Tran, Thao T.D. Tran, Phuong H.L. |
author_facet | Tran, Thao T.D. Tran, Phuong H.L. |
author_sort | Tran, Thao T.D. |
collection | PubMed |
description | Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine. |
format | Online Article Text |
id | pubmed-7463631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74636312020-09-02 Lead Compounds in the Context of Extracellular Vesicle Research Tran, Thao T.D. Tran, Phuong H.L. Pharmaceutics Review Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine. MDPI 2020-07-30 /pmc/articles/PMC7463631/ /pubmed/32751565 http://dx.doi.org/10.3390/pharmaceutics12080716 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tran, Thao T.D. Tran, Phuong H.L. Lead Compounds in the Context of Extracellular Vesicle Research |
title | Lead Compounds in the Context of Extracellular Vesicle Research |
title_full | Lead Compounds in the Context of Extracellular Vesicle Research |
title_fullStr | Lead Compounds in the Context of Extracellular Vesicle Research |
title_full_unstemmed | Lead Compounds in the Context of Extracellular Vesicle Research |
title_short | Lead Compounds in the Context of Extracellular Vesicle Research |
title_sort | lead compounds in the context of extracellular vesicle research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463631/ https://www.ncbi.nlm.nih.gov/pubmed/32751565 http://dx.doi.org/10.3390/pharmaceutics12080716 |
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