Cargando…

Lead Compounds in the Context of Extracellular Vesicle Research

Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an im...

Descripción completa

Detalles Bibliográficos
Autores principales: Tran, Thao T.D., Tran, Phuong H.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463631/
https://www.ncbi.nlm.nih.gov/pubmed/32751565
http://dx.doi.org/10.3390/pharmaceutics12080716
_version_ 1783577176895913984
author Tran, Thao T.D.
Tran, Phuong H.L.
author_facet Tran, Thao T.D.
Tran, Phuong H.L.
author_sort Tran, Thao T.D.
collection PubMed
description Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine.
format Online
Article
Text
id pubmed-7463631
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74636312020-09-02 Lead Compounds in the Context of Extracellular Vesicle Research Tran, Thao T.D. Tran, Phuong H.L. Pharmaceutics Review Studies of small extracellular vesicles (sEVs), known as exosomes, have been flourishing in the last decade with several achievements, from advancing biochemical knowledge to use in biomedical applications. Physiological changes of sEVs due to the variety of cargos they carry undoubtedly leave an impression that affects the understanding of the mechanism underlying disease and the development of sEV-based shuttles used for treatments and non-invasive diagnostic tools. Indeed, the remarkable properties of sEVs are based on their nature, which helps shield them from recognition by the immune system, protects their payload from biochemical degradation, and contributes to their ability to translocate and convey information between cells and their inherent ability to target disease sites such as tumors that is valid for sEVs derived from cancer cells. However, their transport, biogenesis, and secretion mechanisms are still not thoroughly clear, and many ongoing investigations seek to determine how these processes occur. On the other hand, lead compounds have been playing critical roles in the drug discovery process and have been recently employed in studies of the biogenesis and secretion of sEVs as external agents, affecting sEV release and serving as drug payloads in sEV drug delivery systems. This article gives readers an overview of the roles of lead compounds in these two research areas of sEVs, the rising star in studies of nanoscale medicine. MDPI 2020-07-30 /pmc/articles/PMC7463631/ /pubmed/32751565 http://dx.doi.org/10.3390/pharmaceutics12080716 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tran, Thao T.D.
Tran, Phuong H.L.
Lead Compounds in the Context of Extracellular Vesicle Research
title Lead Compounds in the Context of Extracellular Vesicle Research
title_full Lead Compounds in the Context of Extracellular Vesicle Research
title_fullStr Lead Compounds in the Context of Extracellular Vesicle Research
title_full_unstemmed Lead Compounds in the Context of Extracellular Vesicle Research
title_short Lead Compounds in the Context of Extracellular Vesicle Research
title_sort lead compounds in the context of extracellular vesicle research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463631/
https://www.ncbi.nlm.nih.gov/pubmed/32751565
http://dx.doi.org/10.3390/pharmaceutics12080716
work_keys_str_mv AT tranthaotd leadcompoundsinthecontextofextracellularvesicleresearch
AT tranphuonghl leadcompoundsinthecontextofextracellularvesicleresearch