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Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases
Background: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B(12) status in a large cohort of hepatic GSD patients. Methods: Plasma vitamin B(12), t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463656/ https://www.ncbi.nlm.nih.gov/pubmed/32707782 http://dx.doi.org/10.3390/jcm9082326 |
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author | Hinkel, Julia Schmitt, Johannes Wurm, Michael Rosenbaum-Fabian, Stefanie Schwab, Karl Otfried Jacobsen, Donald W. Spiekerkoetter, Ute Fedosov, Sergey N. Hannibal, Luciana Grünert, Sarah C. |
author_facet | Hinkel, Julia Schmitt, Johannes Wurm, Michael Rosenbaum-Fabian, Stefanie Schwab, Karl Otfried Jacobsen, Donald W. Spiekerkoetter, Ute Fedosov, Sergey N. Hannibal, Luciana Grünert, Sarah C. |
author_sort | Hinkel, Julia |
collection | PubMed |
description | Background: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B(12) status in a large cohort of hepatic GSD patients. Methods: Plasma vitamin B(12), total plasma homocysteine (tHcy) and methylmalonic acid concentrations were measured in 44 patients with hepatic GSDs and compared to 42 healthy age- and gender-matched controls. Correlations of vitamin B(12) status with different disease markers of GSDs (including liver transaminase activities and triglycerides) as well as the vitamin B(12) intake were studied. Results: GSD patients had significantly higher plasma vitamin B(12) concentrations than healthy controls (p = 0.0002). Plasma vitamin B(12) concentration remained elevated in GSD patients irrespective of vitamin B(12) intake. Plasma vitamin B(12) concentrations correlated negatively with triglyceride levels, whereas no correlations were detected with liver transaminase activities (GOT and GPT) in GSD patients. Merging biomarker data of healthy controls and GSD patients showed a positive correlation between vitamin B(12) status and liver function, which suggests complex biomarker associations. A combined analysis of biomarkers permitted a reliable clustering of healthy controls versus GSD patients. Conclusions: Elevated plasma concentration of vitamin B(12) (irrespective of B(12) intake) is a common finding in patients with hepatic GSD. The negative correlation of plasma vitamin B(12) with triglyceride levels suggests an influence of metabolic control on the vitamin B(12) status of GSD patients. Elevated vitamin B(12) was not correlated with GOT and GPT in our cohort of GSD patients. Merging of data from healthy controls and GSD patients yielded positive correlations between these biomarkers. This apparent dichotomy highlights the intrinsic complexity of biomarker associations and argues against generalizations of liver disease and elevated vitamin B(12) in blood. Further studies are needed to determine whether the identified associations are causal or coincidental, and the possible impact of chronically elevated vitamin B(12) on GSD. |
format | Online Article Text |
id | pubmed-7463656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74636562020-09-02 Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases Hinkel, Julia Schmitt, Johannes Wurm, Michael Rosenbaum-Fabian, Stefanie Schwab, Karl Otfried Jacobsen, Donald W. Spiekerkoetter, Ute Fedosov, Sergey N. Hannibal, Luciana Grünert, Sarah C. J Clin Med Article Background: Hepatic glycogen storage diseases (GSDs) are inborn errors of metabolism affecting the synthesis or breakdown of glycogen in the liver. This study, for the first time, systematically assessed vitamin B(12) status in a large cohort of hepatic GSD patients. Methods: Plasma vitamin B(12), total plasma homocysteine (tHcy) and methylmalonic acid concentrations were measured in 44 patients with hepatic GSDs and compared to 42 healthy age- and gender-matched controls. Correlations of vitamin B(12) status with different disease markers of GSDs (including liver transaminase activities and triglycerides) as well as the vitamin B(12) intake were studied. Results: GSD patients had significantly higher plasma vitamin B(12) concentrations than healthy controls (p = 0.0002). Plasma vitamin B(12) concentration remained elevated in GSD patients irrespective of vitamin B(12) intake. Plasma vitamin B(12) concentrations correlated negatively with triglyceride levels, whereas no correlations were detected with liver transaminase activities (GOT and GPT) in GSD patients. Merging biomarker data of healthy controls and GSD patients showed a positive correlation between vitamin B(12) status and liver function, which suggests complex biomarker associations. A combined analysis of biomarkers permitted a reliable clustering of healthy controls versus GSD patients. Conclusions: Elevated plasma concentration of vitamin B(12) (irrespective of B(12) intake) is a common finding in patients with hepatic GSD. The negative correlation of plasma vitamin B(12) with triglyceride levels suggests an influence of metabolic control on the vitamin B(12) status of GSD patients. Elevated vitamin B(12) was not correlated with GOT and GPT in our cohort of GSD patients. Merging of data from healthy controls and GSD patients yielded positive correlations between these biomarkers. This apparent dichotomy highlights the intrinsic complexity of biomarker associations and argues against generalizations of liver disease and elevated vitamin B(12) in blood. Further studies are needed to determine whether the identified associations are causal or coincidental, and the possible impact of chronically elevated vitamin B(12) on GSD. MDPI 2020-07-22 /pmc/articles/PMC7463656/ /pubmed/32707782 http://dx.doi.org/10.3390/jcm9082326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hinkel, Julia Schmitt, Johannes Wurm, Michael Rosenbaum-Fabian, Stefanie Schwab, Karl Otfried Jacobsen, Donald W. Spiekerkoetter, Ute Fedosov, Sergey N. Hannibal, Luciana Grünert, Sarah C. Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title | Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title_full | Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title_fullStr | Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title_full_unstemmed | Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title_short | Elevated Plasma Vitamin B(12) in Patients with Hepatic Glycogen Storage Diseases |
title_sort | elevated plasma vitamin b(12) in patients with hepatic glycogen storage diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463656/ https://www.ncbi.nlm.nih.gov/pubmed/32707782 http://dx.doi.org/10.3390/jcm9082326 |
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