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Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction
RNA-binding protein Musashi-1 (MSI1) is a key regulator of several stem cell populations. MSI1 is involved in tumor proliferation and maintenance, and it regulates target mRNAs at the translational level. The known mRNA targets of MSI1 include Numb, APC, and P21(WAF-1), key regulators of Notch/Wnt s...
Autores principales: | Lan, Lan, Liu, Jiajun, Xing, Minli, Smith, Amber R., Wang, Jinan, Wu, Xiaoqing, Appelman, Carl, Li, Ke, Roy, Anuradha, Gowthaman, Ragul, Karanicolas, John, Somoza, Amber D., Wang, Clay C. C., Miao, Yinglong, De Guzman, Roberto, Oakley, Berl R., Neufeld, Kristi L., Xu, Liang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463734/ https://www.ncbi.nlm.nih.gov/pubmed/32784494 http://dx.doi.org/10.3390/cancers12082221 |
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