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Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs

Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g....

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Autores principales: Tran, Thao T. D., Tran, Phuong H. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463741/
https://www.ncbi.nlm.nih.gov/pubmed/32784790
http://dx.doi.org/10.3390/pharmaceutics12080745
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author Tran, Thao T. D.
Tran, Phuong H. L.
author_facet Tran, Thao T. D.
Tran, Phuong H. L.
author_sort Tran, Thao T. D.
collection PubMed
description Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.
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spelling pubmed-74637412020-09-02 Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs Tran, Thao T. D. Tran, Phuong H. L. Pharmaceutics Review Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications. MDPI 2020-08-07 /pmc/articles/PMC7463741/ /pubmed/32784790 http://dx.doi.org/10.3390/pharmaceutics12080745 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tran, Thao T. D.
Tran, Phuong H. L.
Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title_full Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title_fullStr Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title_full_unstemmed Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title_short Molecular Interactions in Solid Dispersions of Poorly Water-Soluble Drugs
title_sort molecular interactions in solid dispersions of poorly water-soluble drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463741/
https://www.ncbi.nlm.nih.gov/pubmed/32784790
http://dx.doi.org/10.3390/pharmaceutics12080745
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