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Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature

We aimed to gain more evidence regarding the feasibility, toxicity, and oncological outcome of primary brachytherapy in patients with medically inoperable endometrial cancer. Thirteen patients receiving primary brachytherapy ± external beam radiotherapy (EBRT) for endometrial cancer due to medical i...

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Autores principales: Arians, Nathalie, Oelmann-Avendano, Jan Tobias, Schmitt, Daniela, Meixner, Eva, Wark, Antje, Hoerner-Rieber, Juliane, El Shafie, Rami A., Lang, Kristin, Wallwiener, Markus, Debus, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463748/
https://www.ncbi.nlm.nih.gov/pubmed/32824243
http://dx.doi.org/10.3390/cancers12082301
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author Arians, Nathalie
Oelmann-Avendano, Jan Tobias
Schmitt, Daniela
Meixner, Eva
Wark, Antje
Hoerner-Rieber, Juliane
El Shafie, Rami A.
Lang, Kristin
Wallwiener, Markus
Debus, Jürgen
author_facet Arians, Nathalie
Oelmann-Avendano, Jan Tobias
Schmitt, Daniela
Meixner, Eva
Wark, Antje
Hoerner-Rieber, Juliane
El Shafie, Rami A.
Lang, Kristin
Wallwiener, Markus
Debus, Jürgen
author_sort Arians, Nathalie
collection PubMed
description We aimed to gain more evidence regarding the feasibility, toxicity, and oncological outcome of primary brachytherapy in patients with medically inoperable endometrial cancer. Thirteen patients receiving primary brachytherapy ± external beam radiotherapy (EBRT) for endometrial cancer due to medical inoperability were identified. The Kaplan–Meier method was used to estimate overall survival (OS), progression-free survival (PFS), and local failure-free survival (LFFS). Univariate outcome analyses were performed using the log-rank test. Peri-interventional complications, acute and chronic toxicities were evaluated. Additionally, we performed a Pubmed search and review of the literature of the last 10 years. Mean age at time of diagnosis was 73.9 years (60.4–87.1 years). Eleven patients were staged FIGO IA/B and one patient each with FIGO IIIA and IIIC. Kaplan–Meier-estimated 2-/5-year LFFS were 76.2%/56.4%, respectively. High grading correlated with a worse LFFS (p = 0.069). Kaplan–Meier-estimated 2-/5-year PFS were 76.9%/53.8% and 2-/5-year-OS were 76.9%/69.2%, respectively. No acute toxicities > grade II and only two late toxicities grade II/III occurred. We observed three peri-interventional complications. The available evidence suggests high rates of local control after definitive brachytherapy for inoperable endometrial cancer with a favorable toxicity profile. Definitive brachytherapy +/− EBRT should be considered as the preferred approach for this patient group.
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spelling pubmed-74637482020-09-02 Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature Arians, Nathalie Oelmann-Avendano, Jan Tobias Schmitt, Daniela Meixner, Eva Wark, Antje Hoerner-Rieber, Juliane El Shafie, Rami A. Lang, Kristin Wallwiener, Markus Debus, Jürgen Cancers (Basel) Article We aimed to gain more evidence regarding the feasibility, toxicity, and oncological outcome of primary brachytherapy in patients with medically inoperable endometrial cancer. Thirteen patients receiving primary brachytherapy ± external beam radiotherapy (EBRT) for endometrial cancer due to medical inoperability were identified. The Kaplan–Meier method was used to estimate overall survival (OS), progression-free survival (PFS), and local failure-free survival (LFFS). Univariate outcome analyses were performed using the log-rank test. Peri-interventional complications, acute and chronic toxicities were evaluated. Additionally, we performed a Pubmed search and review of the literature of the last 10 years. Mean age at time of diagnosis was 73.9 years (60.4–87.1 years). Eleven patients were staged FIGO IA/B and one patient each with FIGO IIIA and IIIC. Kaplan–Meier-estimated 2-/5-year LFFS were 76.2%/56.4%, respectively. High grading correlated with a worse LFFS (p = 0.069). Kaplan–Meier-estimated 2-/5-year PFS were 76.9%/53.8% and 2-/5-year-OS were 76.9%/69.2%, respectively. No acute toxicities > grade II and only two late toxicities grade II/III occurred. We observed three peri-interventional complications. The available evidence suggests high rates of local control after definitive brachytherapy for inoperable endometrial cancer with a favorable toxicity profile. Definitive brachytherapy +/− EBRT should be considered as the preferred approach for this patient group. MDPI 2020-08-15 /pmc/articles/PMC7463748/ /pubmed/32824243 http://dx.doi.org/10.3390/cancers12082301 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arians, Nathalie
Oelmann-Avendano, Jan Tobias
Schmitt, Daniela
Meixner, Eva
Wark, Antje
Hoerner-Rieber, Juliane
El Shafie, Rami A.
Lang, Kristin
Wallwiener, Markus
Debus, Jürgen
Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title_full Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title_fullStr Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title_full_unstemmed Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title_short Evaluation of Uterine Brachytherapy as Primary Treatment Option for Elderly Patients with Medically Inoperable Endometrial Cancer—A Single-Center Experience and Review of the Literature
title_sort evaluation of uterine brachytherapy as primary treatment option for elderly patients with medically inoperable endometrial cancer—a single-center experience and review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463748/
https://www.ncbi.nlm.nih.gov/pubmed/32824243
http://dx.doi.org/10.3390/cancers12082301
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