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Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

In chronic hepatitis C (CHC) patients, interferon-based treatments showed toxicity, limited efficacy, and psychiatric manifestations. Direct-acting antiviral (DAA) agents appeared safer, though it remains unclear if they may exacerbate or foster mood symptoms in drug-naïve CHC patients. We evaluated...

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Autores principales: Fabrazzo, Michele, Zampino, Rosa, Vitrone, Martina, Sampogna, Gaia, Del Gaudio, Lucia, Nunziata, Daniela, Agnese, Salvatore, Santagata, Anna, Durante-Mangoni, Emanuele, Fiorillo, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463817/
https://www.ncbi.nlm.nih.gov/pubmed/32726940
http://dx.doi.org/10.3390/brainsci10080483
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author Fabrazzo, Michele
Zampino, Rosa
Vitrone, Martina
Sampogna, Gaia
Del Gaudio, Lucia
Nunziata, Daniela
Agnese, Salvatore
Santagata, Anna
Durante-Mangoni, Emanuele
Fiorillo, Andrea
author_facet Fabrazzo, Michele
Zampino, Rosa
Vitrone, Martina
Sampogna, Gaia
Del Gaudio, Lucia
Nunziata, Daniela
Agnese, Salvatore
Santagata, Anna
Durante-Mangoni, Emanuele
Fiorillo, Andrea
author_sort Fabrazzo, Michele
collection PubMed
description In chronic hepatitis C (CHC) patients, interferon-based treatments showed toxicity, limited efficacy, and psychiatric manifestations. Direct-acting antiviral (DAA) agents appeared safer, though it remains unclear if they may exacerbate or foster mood symptoms in drug-naïve CHC patients. We evaluated 62 CHC patients’ mental status, before and 12 weeks after DAA therapy, by assessment scales and psychometric instruments. We subdivided patients into two groups, CHC patients with (Group A) or without (Group B) a current and/or past psychiatric history. After DAA treatment, Group A patients showed low anxiety and improved depression, no variation in self-report distress, but worse general health perceptions. No significant difference emerged from coping strategies. Depression and anxiety improved in Group B, and no change emerged from total self-reported distress, except for somatization. Moreover, Group B increased problem-focused strategies for suppression of competing activities, and decreased strategies of instrumental social support. Contrarily, Group B reduced significantly emotion-focused strategies, such as acceptance and mental disengagement, and improved vitality, physical and social role functioning. DAA therapy is safe and free of hepatological and psychiatric side effects in CHC patients, regardless of current and/or past psychiatric history. In particular, patients without a psychiatric history also remarkably improved their quality of life.
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spelling pubmed-74638172020-09-02 Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study Fabrazzo, Michele Zampino, Rosa Vitrone, Martina Sampogna, Gaia Del Gaudio, Lucia Nunziata, Daniela Agnese, Salvatore Santagata, Anna Durante-Mangoni, Emanuele Fiorillo, Andrea Brain Sci Article In chronic hepatitis C (CHC) patients, interferon-based treatments showed toxicity, limited efficacy, and psychiatric manifestations. Direct-acting antiviral (DAA) agents appeared safer, though it remains unclear if they may exacerbate or foster mood symptoms in drug-naïve CHC patients. We evaluated 62 CHC patients’ mental status, before and 12 weeks after DAA therapy, by assessment scales and psychometric instruments. We subdivided patients into two groups, CHC patients with (Group A) or without (Group B) a current and/or past psychiatric history. After DAA treatment, Group A patients showed low anxiety and improved depression, no variation in self-report distress, but worse general health perceptions. No significant difference emerged from coping strategies. Depression and anxiety improved in Group B, and no change emerged from total self-reported distress, except for somatization. Moreover, Group B increased problem-focused strategies for suppression of competing activities, and decreased strategies of instrumental social support. Contrarily, Group B reduced significantly emotion-focused strategies, such as acceptance and mental disengagement, and improved vitality, physical and social role functioning. DAA therapy is safe and free of hepatological and psychiatric side effects in CHC patients, regardless of current and/or past psychiatric history. In particular, patients without a psychiatric history also remarkably improved their quality of life. MDPI 2020-07-27 /pmc/articles/PMC7463817/ /pubmed/32726940 http://dx.doi.org/10.3390/brainsci10080483 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fabrazzo, Michele
Zampino, Rosa
Vitrone, Martina
Sampogna, Gaia
Del Gaudio, Lucia
Nunziata, Daniela
Agnese, Salvatore
Santagata, Anna
Durante-Mangoni, Emanuele
Fiorillo, Andrea
Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title_full Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title_fullStr Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title_full_unstemmed Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title_short Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study
title_sort effects of direct-acting antiviral agents on the mental health of patients with chronic hepatitis c: a prospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463817/
https://www.ncbi.nlm.nih.gov/pubmed/32726940
http://dx.doi.org/10.3390/brainsci10080483
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