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Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration
The demand for highly controllable droplet generation methods is very urgent in the medical, materials, and food industries. The droplet generation in a flow-focusing microfluidic device with external mechanical vibration, as a controllable droplet generation method, is experimentally studied. The e...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463860/ https://www.ncbi.nlm.nih.gov/pubmed/32751579 http://dx.doi.org/10.3390/mi11080743 |
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author | Yin, Zhaoqin Huang, Zemin Lin, Xiaohui Gao, Xiaoyan Bao, Fubing |
author_facet | Yin, Zhaoqin Huang, Zemin Lin, Xiaohui Gao, Xiaoyan Bao, Fubing |
author_sort | Yin, Zhaoqin |
collection | PubMed |
description | The demand for highly controllable droplet generation methods is very urgent in the medical, materials, and food industries. The droplet generation in a flow-focusing microfluidic device with external mechanical vibration, as a controllable droplet generation method, is experimentally studied. The effects of vibration frequency and acceleration amplitude on the droplet generation are characterized. The linear correlation between the droplet generation frequency and the external vibration frequency and the critical vibration amplitude corresponding to the imposing vibration frequency are observed. The droplet generation frequency with external mechanical vibration is affected by the natural generation frequency, vibration frequency, and vibration amplitude. The droplet generation frequency in a certain microfluidic device with external vibration is able to vary from the natural generation frequency to the imposed vibration frequency at different vibration conditions. The evolution of dispersed phase thread with vibration is remarkably different with the process without vibration. Distinct stages of expansion, shrinkage, and collapse are observed in the droplet formation with vibration, and the occurrence number of expansion–shrinkage process is relevant with the linear correlation coefficient. |
format | Online Article Text |
id | pubmed-7463860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74638602020-09-04 Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration Yin, Zhaoqin Huang, Zemin Lin, Xiaohui Gao, Xiaoyan Bao, Fubing Micromachines (Basel) Article The demand for highly controllable droplet generation methods is very urgent in the medical, materials, and food industries. The droplet generation in a flow-focusing microfluidic device with external mechanical vibration, as a controllable droplet generation method, is experimentally studied. The effects of vibration frequency and acceleration amplitude on the droplet generation are characterized. The linear correlation between the droplet generation frequency and the external vibration frequency and the critical vibration amplitude corresponding to the imposing vibration frequency are observed. The droplet generation frequency with external mechanical vibration is affected by the natural generation frequency, vibration frequency, and vibration amplitude. The droplet generation frequency in a certain microfluidic device with external vibration is able to vary from the natural generation frequency to the imposed vibration frequency at different vibration conditions. The evolution of dispersed phase thread with vibration is remarkably different with the process without vibration. Distinct stages of expansion, shrinkage, and collapse are observed in the droplet formation with vibration, and the occurrence number of expansion–shrinkage process is relevant with the linear correlation coefficient. MDPI 2020-07-30 /pmc/articles/PMC7463860/ /pubmed/32751579 http://dx.doi.org/10.3390/mi11080743 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yin, Zhaoqin Huang, Zemin Lin, Xiaohui Gao, Xiaoyan Bao, Fubing Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title | Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title_full | Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title_fullStr | Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title_full_unstemmed | Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title_short | Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration |
title_sort | droplet generation in a flow-focusing microfluidic device with external mechanical vibration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463860/ https://www.ncbi.nlm.nih.gov/pubmed/32751579 http://dx.doi.org/10.3390/mi11080743 |
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