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Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration
Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463929/ https://www.ncbi.nlm.nih.gov/pubmed/32764269 http://dx.doi.org/10.3390/pharmaceutics12080735 |
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author | Tottoli, Erika Maria Dorati, Rossella Genta, Ida Chiesa, Enrica Pisani, Silvia Conti, Bice |
author_facet | Tottoli, Erika Maria Dorati, Rossella Genta, Ida Chiesa, Enrica Pisani, Silvia Conti, Bice |
author_sort | Tottoli, Erika Maria |
collection | PubMed |
description | Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design. |
format | Online Article Text |
id | pubmed-7463929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74639292020-09-04 Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration Tottoli, Erika Maria Dorati, Rossella Genta, Ida Chiesa, Enrica Pisani, Silvia Conti, Bice Pharmaceutics Review Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design. MDPI 2020-08-05 /pmc/articles/PMC7463929/ /pubmed/32764269 http://dx.doi.org/10.3390/pharmaceutics12080735 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tottoli, Erika Maria Dorati, Rossella Genta, Ida Chiesa, Enrica Pisani, Silvia Conti, Bice Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title | Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title_full | Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title_fullStr | Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title_full_unstemmed | Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title_short | Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration |
title_sort | skin wound healing process and new emerging technologies for skin wound care and regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463929/ https://www.ncbi.nlm.nih.gov/pubmed/32764269 http://dx.doi.org/10.3390/pharmaceutics12080735 |
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