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Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies

Synaptic degeneration is an early phenomenon in Parkinson’s disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1 and contactin-2 in cerebrospinal fluid (CSF) of PD patients are reduced compared to dementia with Lewy bodies (DLB) patients and controls and...

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Autores principales: Chatterjee, Madhurima, van Steenoven, Inger, Huisman, Evelien, Oosterveld, Linda, Berendse, Henk, van der Flier, Wiesje M., Del Campo, Marta, Lemstra, Afina W., van de Berg, Wilma D. J., Teunissen, Charlotte E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463939/
https://www.ncbi.nlm.nih.gov/pubmed/32806791
http://dx.doi.org/10.3390/biom10081177
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author Chatterjee, Madhurima
van Steenoven, Inger
Huisman, Evelien
Oosterveld, Linda
Berendse, Henk
van der Flier, Wiesje M.
Del Campo, Marta
Lemstra, Afina W.
van de Berg, Wilma D. J.
Teunissen, Charlotte E.
author_facet Chatterjee, Madhurima
van Steenoven, Inger
Huisman, Evelien
Oosterveld, Linda
Berendse, Henk
van der Flier, Wiesje M.
Del Campo, Marta
Lemstra, Afina W.
van de Berg, Wilma D. J.
Teunissen, Charlotte E.
author_sort Chatterjee, Madhurima
collection PubMed
description Synaptic degeneration is an early phenomenon in Parkinson’s disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1 and contactin-2 in cerebrospinal fluid (CSF) of PD patients are reduced compared to dementia with Lewy bodies (DLB) patients and controls and to evaluate their relationship with α-synuclein aggregation. Contactin-1 and -2 were measured in CSF from PD patients (n = 58), DLB patients (n = 72) and age-matched controls (n = 90). Contactin concentration differences between diagnostic groups were assessed by general linear models adjusted for age and sex. Contactin immunoreactivity was characterized in postmortem substantia nigra, hippocampus and entorhinal cortex tissue of PD patients (n = 4) and controls (n = 4), and its relation to α-syn aggregation was evaluated using confocal laser scanning microscopy. Contactin-1 levels were lower in PD patients (42 (36–49) pg/mL) compared to controls (52 (44–58) pg/mL, p = 0.003) and DLB patients (56 (46–67) pg/mL, p = 0.001). Contactin-2 levels were similar across all diagnostic groups. Within the PD patient group, contactin-1 correlated with t-α-syn, tTau and pTau (r = 0.30–0.50, p < 0.05), whereas contactin-2 only correlated with t-α-syn (r = 0.34, p = 0.03). Contactin-1 and -2 were observed within nigral and cortical Lewy bodies and clustered within bulgy Lewy neurites in PD brains. A decrease in CSF contactin-1 may reflect synaptic degeneration underlying Lewy body pathology in PD.
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spelling pubmed-74639392020-09-04 Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies Chatterjee, Madhurima van Steenoven, Inger Huisman, Evelien Oosterveld, Linda Berendse, Henk van der Flier, Wiesje M. Del Campo, Marta Lemstra, Afina W. van de Berg, Wilma D. J. Teunissen, Charlotte E. Biomolecules Article Synaptic degeneration is an early phenomenon in Parkinson’s disease (PD) pathogenesis. We aimed to investigate whether levels of synaptic proteins contactin-1 and contactin-2 in cerebrospinal fluid (CSF) of PD patients are reduced compared to dementia with Lewy bodies (DLB) patients and controls and to evaluate their relationship with α-synuclein aggregation. Contactin-1 and -2 were measured in CSF from PD patients (n = 58), DLB patients (n = 72) and age-matched controls (n = 90). Contactin concentration differences between diagnostic groups were assessed by general linear models adjusted for age and sex. Contactin immunoreactivity was characterized in postmortem substantia nigra, hippocampus and entorhinal cortex tissue of PD patients (n = 4) and controls (n = 4), and its relation to α-syn aggregation was evaluated using confocal laser scanning microscopy. Contactin-1 levels were lower in PD patients (42 (36–49) pg/mL) compared to controls (52 (44–58) pg/mL, p = 0.003) and DLB patients (56 (46–67) pg/mL, p = 0.001). Contactin-2 levels were similar across all diagnostic groups. Within the PD patient group, contactin-1 correlated with t-α-syn, tTau and pTau (r = 0.30–0.50, p < 0.05), whereas contactin-2 only correlated with t-α-syn (r = 0.34, p = 0.03). Contactin-1 and -2 were observed within nigral and cortical Lewy bodies and clustered within bulgy Lewy neurites in PD brains. A decrease in CSF contactin-1 may reflect synaptic degeneration underlying Lewy body pathology in PD. MDPI 2020-08-12 /pmc/articles/PMC7463939/ /pubmed/32806791 http://dx.doi.org/10.3390/biom10081177 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chatterjee, Madhurima
van Steenoven, Inger
Huisman, Evelien
Oosterveld, Linda
Berendse, Henk
van der Flier, Wiesje M.
Del Campo, Marta
Lemstra, Afina W.
van de Berg, Wilma D. J.
Teunissen, Charlotte E.
Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title_full Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title_fullStr Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title_full_unstemmed Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title_short Contactin-1 Is Reduced in Cerebrospinal Fluid of Parkinson’s Disease Patients and Is Present within Lewy Bodies
title_sort contactin-1 is reduced in cerebrospinal fluid of parkinson’s disease patients and is present within lewy bodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463939/
https://www.ncbi.nlm.nih.gov/pubmed/32806791
http://dx.doi.org/10.3390/biom10081177
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