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Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism

In symptomatic acute pulmonary embolism (PE), the presence of deep vein thrombosis (DVT) is a risk factor for 30- and 90-day mortality. In patients with cancer and incidental PE, the prognostic effect of concomitant incidental DVT is unknown. In this retrospective study, we examined the effect of in...

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Autores principales: Barca-Hernando, Maria, Ortega-Rivera, Rocio, Lopez-Ruz, Sergio, Elias-Hernandez, Teresa, Asensio-Cruz, Maria Isabel, Marin-Romero, Samira, Toral, Javier, Montero, Emilio, Sanchez, Veronica, Arellano, Elena, Sanchez-Diaz, Jose Maria, Real-Dominguez, Macarena, Otero-Candelera, Remedios, Jara-Palomares, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463961/
https://www.ncbi.nlm.nih.gov/pubmed/32823554
http://dx.doi.org/10.3390/cancers12082267
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author Barca-Hernando, Maria
Ortega-Rivera, Rocio
Lopez-Ruz, Sergio
Elias-Hernandez, Teresa
Asensio-Cruz, Maria Isabel
Marin-Romero, Samira
Toral, Javier
Montero, Emilio
Sanchez, Veronica
Arellano, Elena
Sanchez-Diaz, Jose Maria
Real-Dominguez, Macarena
Otero-Candelera, Remedios
Jara-Palomares, Luis
author_facet Barca-Hernando, Maria
Ortega-Rivera, Rocio
Lopez-Ruz, Sergio
Elias-Hernandez, Teresa
Asensio-Cruz, Maria Isabel
Marin-Romero, Samira
Toral, Javier
Montero, Emilio
Sanchez, Veronica
Arellano, Elena
Sanchez-Diaz, Jose Maria
Real-Dominguez, Macarena
Otero-Candelera, Remedios
Jara-Palomares, Luis
author_sort Barca-Hernando, Maria
collection PubMed
description In symptomatic acute pulmonary embolism (PE), the presence of deep vein thrombosis (DVT) is a risk factor for 30- and 90-day mortality. In patients with cancer and incidental PE, the prognostic effect of concomitant incidental DVT is unknown. In this retrospective study, we examined the effect of incidental DVT on all-cause mortality in such patients. Adjusted Cox multivariate regression analysis was used for relevant covariates. From January 2010 to March 2018, we included 200 patients (mean age, 65.3 ± 12.4 years) who were followed up for 12.5 months (interquartile range 7.4–19.4 months). Of these patients, 62% had metastases, 31% had concomitant incidental DVT, and 40.1% (n = 81) died during follow-up. All-cause mortality did not increase in patients with DVT (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.43–2.75, p = 0.855). On multivariate analysis, weight (adjusted HR 0.96, 95% CI 0.92–0.99, p = 0.032), and metastasis (adjusted HR 10.26, 95% CI 2.35–44.9, p = 0.002) were predictors of all-cause mortality. In conclusion, low weight and presence of metastases were associated with all-cause mortality, while presence of concomitant DVT was unrelated to poorer survival.
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spelling pubmed-74639612020-09-04 Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism Barca-Hernando, Maria Ortega-Rivera, Rocio Lopez-Ruz, Sergio Elias-Hernandez, Teresa Asensio-Cruz, Maria Isabel Marin-Romero, Samira Toral, Javier Montero, Emilio Sanchez, Veronica Arellano, Elena Sanchez-Diaz, Jose Maria Real-Dominguez, Macarena Otero-Candelera, Remedios Jara-Palomares, Luis Cancers (Basel) Article In symptomatic acute pulmonary embolism (PE), the presence of deep vein thrombosis (DVT) is a risk factor for 30- and 90-day mortality. In patients with cancer and incidental PE, the prognostic effect of concomitant incidental DVT is unknown. In this retrospective study, we examined the effect of incidental DVT on all-cause mortality in such patients. Adjusted Cox multivariate regression analysis was used for relevant covariates. From January 2010 to March 2018, we included 200 patients (mean age, 65.3 ± 12.4 years) who were followed up for 12.5 months (interquartile range 7.4–19.4 months). Of these patients, 62% had metastases, 31% had concomitant incidental DVT, and 40.1% (n = 81) died during follow-up. All-cause mortality did not increase in patients with DVT (hazard ratio [HR] 1.01, 95% confidence interval [CI] 0.43–2.75, p = 0.855). On multivariate analysis, weight (adjusted HR 0.96, 95% CI 0.92–0.99, p = 0.032), and metastasis (adjusted HR 10.26, 95% CI 2.35–44.9, p = 0.002) were predictors of all-cause mortality. In conclusion, low weight and presence of metastases were associated with all-cause mortality, while presence of concomitant DVT was unrelated to poorer survival. MDPI 2020-08-13 /pmc/articles/PMC7463961/ /pubmed/32823554 http://dx.doi.org/10.3390/cancers12082267 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barca-Hernando, Maria
Ortega-Rivera, Rocio
Lopez-Ruz, Sergio
Elias-Hernandez, Teresa
Asensio-Cruz, Maria Isabel
Marin-Romero, Samira
Toral, Javier
Montero, Emilio
Sanchez, Veronica
Arellano, Elena
Sanchez-Diaz, Jose Maria
Real-Dominguez, Macarena
Otero-Candelera, Remedios
Jara-Palomares, Luis
Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title_full Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title_fullStr Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title_full_unstemmed Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title_short Prognostic Significance of Incidental Deep Vein Thrombosis in Patients with Cancer Presenting with Incidental Pulmonary Embolism
title_sort prognostic significance of incidental deep vein thrombosis in patients with cancer presenting with incidental pulmonary embolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463961/
https://www.ncbi.nlm.nih.gov/pubmed/32823554
http://dx.doi.org/10.3390/cancers12082267
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