Cargando…

Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond

Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard f...

Descripción completa

Detalles Bibliográficos
Autores principales: Le Blanc, Jessica, Mullier, François, Vayne, Caroline, Lordkipanidzé, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464122/
https://www.ncbi.nlm.nih.gov/pubmed/32823782
http://dx.doi.org/10.3390/jcm9082636
_version_ 1783577291149803520
author Le Blanc, Jessica
Mullier, François
Vayne, Caroline
Lordkipanidzé, Marie
author_facet Le Blanc, Jessica
Mullier, François
Vayne, Caroline
Lordkipanidzé, Marie
author_sort Le Blanc, Jessica
collection PubMed
description Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications.
format Online
Article
Text
id pubmed-7464122
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-74641222020-09-04 Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond Le Blanc, Jessica Mullier, François Vayne, Caroline Lordkipanidzé, Marie J Clin Med Review Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications. MDPI 2020-08-13 /pmc/articles/PMC7464122/ /pubmed/32823782 http://dx.doi.org/10.3390/jcm9082636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Le Blanc, Jessica
Mullier, François
Vayne, Caroline
Lordkipanidzé, Marie
Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title_full Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title_fullStr Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title_full_unstemmed Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title_short Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
title_sort advances in platelet function testing—light transmission aggregometry and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464122/
https://www.ncbi.nlm.nih.gov/pubmed/32823782
http://dx.doi.org/10.3390/jcm9082636
work_keys_str_mv AT leblancjessica advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond
AT mullierfrancois advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond
AT vaynecaroline advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond
AT lordkipanidzemarie advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond