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Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464122/ https://www.ncbi.nlm.nih.gov/pubmed/32823782 http://dx.doi.org/10.3390/jcm9082636 |
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author | Le Blanc, Jessica Mullier, François Vayne, Caroline Lordkipanidzé, Marie |
author_facet | Le Blanc, Jessica Mullier, François Vayne, Caroline Lordkipanidzé, Marie |
author_sort | Le Blanc, Jessica |
collection | PubMed |
description | Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications. |
format | Online Article Text |
id | pubmed-7464122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74641222020-09-04 Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond Le Blanc, Jessica Mullier, François Vayne, Caroline Lordkipanidzé, Marie J Clin Med Review Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light transmission aggregometry has been the gold standard for over 60 years, with inherent challenges of working with live dynamic cells in specialized laboratories with independent protocols. In recent years, standardization efforts have brought forward fully automated systems that could lead to more widespread use. Additionally, new technical approaches appear promising for the future of specialized hematology laboratories. This review presents developments in platelet function testing for clinical applications. MDPI 2020-08-13 /pmc/articles/PMC7464122/ /pubmed/32823782 http://dx.doi.org/10.3390/jcm9082636 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Le Blanc, Jessica Mullier, François Vayne, Caroline Lordkipanidzé, Marie Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title_full | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title_fullStr | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title_full_unstemmed | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title_short | Advances in Platelet Function Testing—Light Transmission Aggregometry and Beyond |
title_sort | advances in platelet function testing—light transmission aggregometry and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464122/ https://www.ncbi.nlm.nih.gov/pubmed/32823782 http://dx.doi.org/10.3390/jcm9082636 |
work_keys_str_mv | AT leblancjessica advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond AT mullierfrancois advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond AT vaynecaroline advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond AT lordkipanidzemarie advancesinplateletfunctiontestinglighttransmissionaggregometryandbeyond |