Genetic Susceptibility of the Host in Virus-Induced Diabetes

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be co...

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Detalles Bibliográficos
Autores principales: Mine, Keiichiro, Yoshikai, Yasunobu, Takahashi, Hirokazu, Mori, Hitoe, Anzai, Keizo, Nagafuchi, Seiho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464158/
https://www.ncbi.nlm.nih.gov/pubmed/32727064
http://dx.doi.org/10.3390/microorganisms8081133
Descripción
Sumario:Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.

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