Genetic Susceptibility of the Host in Virus-Induced Diabetes

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be co...

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Autores principales: Mine, Keiichiro, Yoshikai, Yasunobu, Takahashi, Hirokazu, Mori, Hitoe, Anzai, Keizo, Nagafuchi, Seiho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464158/
https://www.ncbi.nlm.nih.gov/pubmed/32727064
http://dx.doi.org/10.3390/microorganisms8081133
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author Mine, Keiichiro
Yoshikai, Yasunobu
Takahashi, Hirokazu
Mori, Hitoe
Anzai, Keizo
Nagafuchi, Seiho
author_facet Mine, Keiichiro
Yoshikai, Yasunobu
Takahashi, Hirokazu
Mori, Hitoe
Anzai, Keizo
Nagafuchi, Seiho
author_sort Mine, Keiichiro
collection PubMed
description Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.
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spelling pubmed-74641582020-09-04 Genetic Susceptibility of the Host in Virus-Induced Diabetes Mine, Keiichiro Yoshikai, Yasunobu Takahashi, Hirokazu Mori, Hitoe Anzai, Keizo Nagafuchi, Seiho Microorganisms Review Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID. MDPI 2020-07-27 /pmc/articles/PMC7464158/ /pubmed/32727064 http://dx.doi.org/10.3390/microorganisms8081133 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mine, Keiichiro
Yoshikai, Yasunobu
Takahashi, Hirokazu
Mori, Hitoe
Anzai, Keizo
Nagafuchi, Seiho
Genetic Susceptibility of the Host in Virus-Induced Diabetes
title Genetic Susceptibility of the Host in Virus-Induced Diabetes
title_full Genetic Susceptibility of the Host in Virus-Induced Diabetes
title_fullStr Genetic Susceptibility of the Host in Virus-Induced Diabetes
title_full_unstemmed Genetic Susceptibility of the Host in Virus-Induced Diabetes
title_short Genetic Susceptibility of the Host in Virus-Induced Diabetes
title_sort genetic susceptibility of the host in virus-induced diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464158/
https://www.ncbi.nlm.nih.gov/pubmed/32727064
http://dx.doi.org/10.3390/microorganisms8081133
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AT morihitoe geneticsusceptibilityofthehostinvirusinduceddiabetes
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