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Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464171/ https://www.ncbi.nlm.nih.gov/pubmed/32806645 http://dx.doi.org/10.3390/jcm9082616 |
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author | Mechelinck, Mare Hartmann, Bianca Hamada, Sandra Becker, Michael Andert, Anne Ulmer, Tom Florian Neumann, Ulf Peter Wirtz, Theresa Hildegard Koch, Alexander Trautwein, Christian Roehl, Anna Bettina Rossaint, Rolf Hein, Marc |
author_facet | Mechelinck, Mare Hartmann, Bianca Hamada, Sandra Becker, Michael Andert, Anne Ulmer, Tom Florian Neumann, Ulf Peter Wirtz, Theresa Hildegard Koch, Alexander Trautwein, Christian Roehl, Anna Bettina Rossaint, Rolf Hein, Marc |
author_sort | Mechelinck, Mare |
collection | PubMed |
description | Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a single center between May 2010 and April 2016 with normal left ventricular ejection fraction were included according to clinical characteristics of their liver disease: (1) compensated (n = 29), (2) clinically significant portal hypertension (n = 49), and (3) decompensated (n = 39). Standard echocardiography and speckle tracking echocardiography were performed at rest and during dobutamine stress. Follow-up amounted to three years to evaluate survival and major cardiac events. Altogether 67% (78/117) of the patients were transplanted and 32% (31/96 patients) died during the three-year follow-up period. Global longitudinal strain (GLS) at rest was significantly increased (became more negative) with the severity of liver disease (p < 0.001), but reached comparable values in all groups during peak stress. Low (less negative) GLS values at rest (male: >−17/female: >−18%) could predict patient survival in a multivariate Cox regression analysis (p = 0.002). GLS proved valuable in identifying transplant candidates with latent systolic dysfunction. |
format | Online Article Text |
id | pubmed-7464171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74641712020-09-04 Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study Mechelinck, Mare Hartmann, Bianca Hamada, Sandra Becker, Michael Andert, Anne Ulmer, Tom Florian Neumann, Ulf Peter Wirtz, Theresa Hildegard Koch, Alexander Trautwein, Christian Roehl, Anna Bettina Rossaint, Rolf Hein, Marc J Clin Med Article Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a single center between May 2010 and April 2016 with normal left ventricular ejection fraction were included according to clinical characteristics of their liver disease: (1) compensated (n = 29), (2) clinically significant portal hypertension (n = 49), and (3) decompensated (n = 39). Standard echocardiography and speckle tracking echocardiography were performed at rest and during dobutamine stress. Follow-up amounted to three years to evaluate survival and major cardiac events. Altogether 67% (78/117) of the patients were transplanted and 32% (31/96 patients) died during the three-year follow-up period. Global longitudinal strain (GLS) at rest was significantly increased (became more negative) with the severity of liver disease (p < 0.001), but reached comparable values in all groups during peak stress. Low (less negative) GLS values at rest (male: >−17/female: >−18%) could predict patient survival in a multivariate Cox regression analysis (p = 0.002). GLS proved valuable in identifying transplant candidates with latent systolic dysfunction. MDPI 2020-08-12 /pmc/articles/PMC7464171/ /pubmed/32806645 http://dx.doi.org/10.3390/jcm9082616 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mechelinck, Mare Hartmann, Bianca Hamada, Sandra Becker, Michael Andert, Anne Ulmer, Tom Florian Neumann, Ulf Peter Wirtz, Theresa Hildegard Koch, Alexander Trautwein, Christian Roehl, Anna Bettina Rossaint, Rolf Hein, Marc Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title | Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title_full | Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title_fullStr | Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title_full_unstemmed | Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title_short | Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study |
title_sort | global longitudinal strain at rest as an independent predictor of mortality in liver transplant candidates: a retrospective clinical study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464171/ https://www.ncbi.nlm.nih.gov/pubmed/32806645 http://dx.doi.org/10.3390/jcm9082616 |
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