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Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study

Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a...

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Autores principales: Mechelinck, Mare, Hartmann, Bianca, Hamada, Sandra, Becker, Michael, Andert, Anne, Ulmer, Tom Florian, Neumann, Ulf Peter, Wirtz, Theresa Hildegard, Koch, Alexander, Trautwein, Christian, Roehl, Anna Bettina, Rossaint, Rolf, Hein, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464171/
https://www.ncbi.nlm.nih.gov/pubmed/32806645
http://dx.doi.org/10.3390/jcm9082616
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author Mechelinck, Mare
Hartmann, Bianca
Hamada, Sandra
Becker, Michael
Andert, Anne
Ulmer, Tom Florian
Neumann, Ulf Peter
Wirtz, Theresa Hildegard
Koch, Alexander
Trautwein, Christian
Roehl, Anna Bettina
Rossaint, Rolf
Hein, Marc
author_facet Mechelinck, Mare
Hartmann, Bianca
Hamada, Sandra
Becker, Michael
Andert, Anne
Ulmer, Tom Florian
Neumann, Ulf Peter
Wirtz, Theresa Hildegard
Koch, Alexander
Trautwein, Christian
Roehl, Anna Bettina
Rossaint, Rolf
Hein, Marc
author_sort Mechelinck, Mare
collection PubMed
description Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a single center between May 2010 and April 2016 with normal left ventricular ejection fraction were included according to clinical characteristics of their liver disease: (1) compensated (n = 29), (2) clinically significant portal hypertension (n = 49), and (3) decompensated (n = 39). Standard echocardiography and speckle tracking echocardiography were performed at rest and during dobutamine stress. Follow-up amounted to three years to evaluate survival and major cardiac events. Altogether 67% (78/117) of the patients were transplanted and 32% (31/96 patients) died during the three-year follow-up period. Global longitudinal strain (GLS) at rest was significantly increased (became more negative) with the severity of liver disease (p < 0.001), but reached comparable values in all groups during peak stress. Low (less negative) GLS values at rest (male: >−17/female: >−18%) could predict patient survival in a multivariate Cox regression analysis (p = 0.002). GLS proved valuable in identifying transplant candidates with latent systolic dysfunction.
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spelling pubmed-74641712020-09-04 Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study Mechelinck, Mare Hartmann, Bianca Hamada, Sandra Becker, Michael Andert, Anne Ulmer, Tom Florian Neumann, Ulf Peter Wirtz, Theresa Hildegard Koch, Alexander Trautwein, Christian Roehl, Anna Bettina Rossaint, Rolf Hein, Marc J Clin Med Article Speckle tracking echocardiography enables the detection of subclinical left ventricular dysfunction at rest in many heart diseases and potentially in severe liver diseases. It could also possibly serve as a predictor for survival. In this study, 117 patients evaluated for liver transplantation in a single center between May 2010 and April 2016 with normal left ventricular ejection fraction were included according to clinical characteristics of their liver disease: (1) compensated (n = 29), (2) clinically significant portal hypertension (n = 49), and (3) decompensated (n = 39). Standard echocardiography and speckle tracking echocardiography were performed at rest and during dobutamine stress. Follow-up amounted to three years to evaluate survival and major cardiac events. Altogether 67% (78/117) of the patients were transplanted and 32% (31/96 patients) died during the three-year follow-up period. Global longitudinal strain (GLS) at rest was significantly increased (became more negative) with the severity of liver disease (p < 0.001), but reached comparable values in all groups during peak stress. Low (less negative) GLS values at rest (male: >−17/female: >−18%) could predict patient survival in a multivariate Cox regression analysis (p = 0.002). GLS proved valuable in identifying transplant candidates with latent systolic dysfunction. MDPI 2020-08-12 /pmc/articles/PMC7464171/ /pubmed/32806645 http://dx.doi.org/10.3390/jcm9082616 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mechelinck, Mare
Hartmann, Bianca
Hamada, Sandra
Becker, Michael
Andert, Anne
Ulmer, Tom Florian
Neumann, Ulf Peter
Wirtz, Theresa Hildegard
Koch, Alexander
Trautwein, Christian
Roehl, Anna Bettina
Rossaint, Rolf
Hein, Marc
Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title_full Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title_fullStr Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title_full_unstemmed Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title_short Global Longitudinal Strain at Rest as an Independent Predictor of Mortality in Liver Transplant Candidates: A Retrospective Clinical Study
title_sort global longitudinal strain at rest as an independent predictor of mortality in liver transplant candidates: a retrospective clinical study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464171/
https://www.ncbi.nlm.nih.gov/pubmed/32806645
http://dx.doi.org/10.3390/jcm9082616
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