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Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea

Corydalis and Pseudofumaria are two closely related genera from the Papaveraceae subfamily Fumarioideae with Corydalis solida (C. solida) and Pseudofumaria lutea (P. lutea) as two representative species. Phytochemical analysis revealed significant differences in the quality and quantity of isoquinol...

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Autores principales: Zielińska, Sylwia, Dziągwa-Becker, Magdalena, Piątczak, Ewelina, Jezierska-Domaradzka, Anna, Brożyna, Malwina, Junka, Adam, Kucharski, Mariusz, Çiçek, Serhat Sezai, Zidorn, Christian, Matkowski, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464254/
https://www.ncbi.nlm.nih.gov/pubmed/32784618
http://dx.doi.org/10.3390/molecules25163591
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author Zielińska, Sylwia
Dziągwa-Becker, Magdalena
Piątczak, Ewelina
Jezierska-Domaradzka, Anna
Brożyna, Malwina
Junka, Adam
Kucharski, Mariusz
Çiçek, Serhat Sezai
Zidorn, Christian
Matkowski, Adam
author_facet Zielińska, Sylwia
Dziągwa-Becker, Magdalena
Piątczak, Ewelina
Jezierska-Domaradzka, Anna
Brożyna, Malwina
Junka, Adam
Kucharski, Mariusz
Çiçek, Serhat Sezai
Zidorn, Christian
Matkowski, Adam
author_sort Zielińska, Sylwia
collection PubMed
description Corydalis and Pseudofumaria are two closely related genera from the Papaveraceae subfamily Fumarioideae with Corydalis solida (C. solida) and Pseudofumaria lutea (P. lutea) as two representative species. Phytochemical analysis revealed significant differences in the quality and quantity of isoquinoline alkaloids, phenolic compounds and non-phenolic carboxylic acids between aerial and underground parts of both species. Using the Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) technique, 21 compounds were identified: five protoberberine derivatives, three protopine derivatives, four phenanthridine derivatives, as well as three carboxylic acids, two hydroxycinnamic acids, one chlorogenic acid, one phenolic aldehyde, and two flavonoids. Moroever, significant differences in the content of individual compounds were observed between the two studied species. The phytochemical profile of C. solida showed a higher variety of compounds that were present in lower amounts, whereas P. lutea extracts contained fewer compounds but in larger quantities. Protopine was one of the most abundant constituents in C. solida (440–1125 µg/g d.w.) and in P. lutea (1036–1934 µg/g d.w.). Moreover, considerable amounts of coptisine (1526 µg/g) and quercetin (3247 µg/g) were detected in the aerial parts of P. lutea. Extracts from aerial and underground parts of both species were also examined for the antimicrobial potential against S. aureus, P. aeruginosa and C. albicans. P. lutea herb extract was the most effective (MIC at 0.39 mg/L) against all three pathogens.
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spelling pubmed-74642542020-09-04 Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea Zielińska, Sylwia Dziągwa-Becker, Magdalena Piątczak, Ewelina Jezierska-Domaradzka, Anna Brożyna, Malwina Junka, Adam Kucharski, Mariusz Çiçek, Serhat Sezai Zidorn, Christian Matkowski, Adam Molecules Article Corydalis and Pseudofumaria are two closely related genera from the Papaveraceae subfamily Fumarioideae with Corydalis solida (C. solida) and Pseudofumaria lutea (P. lutea) as two representative species. Phytochemical analysis revealed significant differences in the quality and quantity of isoquinoline alkaloids, phenolic compounds and non-phenolic carboxylic acids between aerial and underground parts of both species. Using the Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) technique, 21 compounds were identified: five protoberberine derivatives, three protopine derivatives, four phenanthridine derivatives, as well as three carboxylic acids, two hydroxycinnamic acids, one chlorogenic acid, one phenolic aldehyde, and two flavonoids. Moroever, significant differences in the content of individual compounds were observed between the two studied species. The phytochemical profile of C. solida showed a higher variety of compounds that were present in lower amounts, whereas P. lutea extracts contained fewer compounds but in larger quantities. Protopine was one of the most abundant constituents in C. solida (440–1125 µg/g d.w.) and in P. lutea (1036–1934 µg/g d.w.). Moreover, considerable amounts of coptisine (1526 µg/g) and quercetin (3247 µg/g) were detected in the aerial parts of P. lutea. Extracts from aerial and underground parts of both species were also examined for the antimicrobial potential against S. aureus, P. aeruginosa and C. albicans. P. lutea herb extract was the most effective (MIC at 0.39 mg/L) against all three pathogens. MDPI 2020-08-07 /pmc/articles/PMC7464254/ /pubmed/32784618 http://dx.doi.org/10.3390/molecules25163591 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zielińska, Sylwia
Dziągwa-Becker, Magdalena
Piątczak, Ewelina
Jezierska-Domaradzka, Anna
Brożyna, Malwina
Junka, Adam
Kucharski, Mariusz
Çiçek, Serhat Sezai
Zidorn, Christian
Matkowski, Adam
Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title_full Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title_fullStr Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title_full_unstemmed Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title_short Phytochemical Composition and Antimicrobial Activity of Corydalis solida and Pseudofumaria lutea
title_sort phytochemical composition and antimicrobial activity of corydalis solida and pseudofumaria lutea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464254/
https://www.ncbi.nlm.nih.gov/pubmed/32784618
http://dx.doi.org/10.3390/molecules25163591
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