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Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children

Obesity is a major health problem worldwide and constitutes a sanitary emergency in Mexico, especially childhood obesity. Several studies have proved the relationship between obesity and oxidative stress and the influence of genetic predisposition. This work was aimed to analyze the association of a...

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Autores principales: Costa-Urrutia, Paula, Flores-Buendía, Aline Mariana, Ascencio-Montiel, Iván, Solares-Tlapechco, Jacqueline, Medina-Campos, Omar Noel, Pedraza-Chaverri, José, Granados, Julio, Jiménez-Osorio, Angélica Saraí, Rodríguez-Arellano, Martha Eunice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464274/
https://www.ncbi.nlm.nih.gov/pubmed/32752212
http://dx.doi.org/10.3390/antiox9080684
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author Costa-Urrutia, Paula
Flores-Buendía, Aline Mariana
Ascencio-Montiel, Iván
Solares-Tlapechco, Jacqueline
Medina-Campos, Omar Noel
Pedraza-Chaverri, José
Granados, Julio
Jiménez-Osorio, Angélica Saraí
Rodríguez-Arellano, Martha Eunice
author_facet Costa-Urrutia, Paula
Flores-Buendía, Aline Mariana
Ascencio-Montiel, Iván
Solares-Tlapechco, Jacqueline
Medina-Campos, Omar Noel
Pedraza-Chaverri, José
Granados, Julio
Jiménez-Osorio, Angélica Saraí
Rodríguez-Arellano, Martha Eunice
author_sort Costa-Urrutia, Paula
collection PubMed
description Obesity is a major health problem worldwide and constitutes a sanitary emergency in Mexico, especially childhood obesity. Several studies have proved the relationship between obesity and oxidative stress and the influence of genetic predisposition. This work was aimed to analyze the association of antioxidant enzyme polymorphisms with overweight and obesity in Mexican children and adolescents. A case-control study was performed in 585 children and adolescents aged 3 to 17 years, using two criteria to classify obesity: body mass index (BMI) and body fat percentage (BFP). Anthropometric and biochemical measurements were carried out, and malondialdehyde serum levels were determined. Genotyping was done with the Axiom Genome-Wide LAT microarray, including 68 single nucleotide polymorphisms (SNPs) of the glutathione peroxidase (GPX) and paraoxonase (PON) families. We found six haplotypes associated with obesity—two of them (one in GPX3 and the other in GPX5 and GPX6) in a protective direction when obesity was classified by BMI. The other four haplotypes were associated with obesity when classification was based on BFP—one of them in GPX3 in a protective direction and the others in PON genes conferring obesity risk. In addition, two SNPs, GPX3 rs922429 and GPX4 rs2074451 showed protection against obesity classified by BFP. This study showed genetic susceptibility to oxidative stress in relation to obesity in Mexican children and opens up the possibility that some genetic loci related to obesity are not identified when weight classification is based on BMI.
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spelling pubmed-74642742020-09-04 Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children Costa-Urrutia, Paula Flores-Buendía, Aline Mariana Ascencio-Montiel, Iván Solares-Tlapechco, Jacqueline Medina-Campos, Omar Noel Pedraza-Chaverri, José Granados, Julio Jiménez-Osorio, Angélica Saraí Rodríguez-Arellano, Martha Eunice Antioxidants (Basel) Article Obesity is a major health problem worldwide and constitutes a sanitary emergency in Mexico, especially childhood obesity. Several studies have proved the relationship between obesity and oxidative stress and the influence of genetic predisposition. This work was aimed to analyze the association of antioxidant enzyme polymorphisms with overweight and obesity in Mexican children and adolescents. A case-control study was performed in 585 children and adolescents aged 3 to 17 years, using two criteria to classify obesity: body mass index (BMI) and body fat percentage (BFP). Anthropometric and biochemical measurements were carried out, and malondialdehyde serum levels were determined. Genotyping was done with the Axiom Genome-Wide LAT microarray, including 68 single nucleotide polymorphisms (SNPs) of the glutathione peroxidase (GPX) and paraoxonase (PON) families. We found six haplotypes associated with obesity—two of them (one in GPX3 and the other in GPX5 and GPX6) in a protective direction when obesity was classified by BMI. The other four haplotypes were associated with obesity when classification was based on BFP—one of them in GPX3 in a protective direction and the others in PON genes conferring obesity risk. In addition, two SNPs, GPX3 rs922429 and GPX4 rs2074451 showed protection against obesity classified by BFP. This study showed genetic susceptibility to oxidative stress in relation to obesity in Mexican children and opens up the possibility that some genetic loci related to obesity are not identified when weight classification is based on BMI. MDPI 2020-08-01 /pmc/articles/PMC7464274/ /pubmed/32752212 http://dx.doi.org/10.3390/antiox9080684 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Costa-Urrutia, Paula
Flores-Buendía, Aline Mariana
Ascencio-Montiel, Iván
Solares-Tlapechco, Jacqueline
Medina-Campos, Omar Noel
Pedraza-Chaverri, José
Granados, Julio
Jiménez-Osorio, Angélica Saraí
Rodríguez-Arellano, Martha Eunice
Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title_full Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title_fullStr Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title_full_unstemmed Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title_short Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity in Mexican Children
title_sort antioxidant enzymes haplotypes and polymorphisms associated with obesity in mexican children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464274/
https://www.ncbi.nlm.nih.gov/pubmed/32752212
http://dx.doi.org/10.3390/antiox9080684
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