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Imaging Bacteria with Radiolabelled Probes: Is It Feasible?

Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros...

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Autores principales: Signore, Alberto, Artiko, Vera, Conserva, Martina, Ferro-Flores, Guillermina, Welling, Mick M., Jain, Sanjay K., Hess, Søren, Sathekge, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464306/
https://www.ncbi.nlm.nih.gov/pubmed/32722355
http://dx.doi.org/10.3390/jcm9082372
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author Signore, Alberto
Artiko, Vera
Conserva, Martina
Ferro-Flores, Guillermina
Welling, Mick M.
Jain, Sanjay K.
Hess, Søren
Sathekge, Mike
author_facet Signore, Alberto
Artiko, Vera
Conserva, Martina
Ferro-Flores, Guillermina
Welling, Mick M.
Jain, Sanjay K.
Hess, Søren
Sathekge, Mike
author_sort Signore, Alberto
collection PubMed
description Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros and cons. Molecular nuclear medicine has highly contributed in this field by proposing several different radiopharmaceuticals (antimicrobial peptides, leukocytes, cytokines, antibiotics, sugars, etc.) but none proved to be highly specific for bacteria, although many agents in development look promising. Indeed, factors including the number and strain of bacteria, the infection site, and the host condition, may affect the specificity of the tested radiopharmaceuticals. At the Third European Congress on Infection/Inflammation Imaging, a round table discussion was dedicated to debate the pros and cons of different radiopharmaceuticals for imaging bacteria with the final goal to find a consensus on the most relevant research steps that should be fulfilled when testing a new probe, based on experience and cumulative published evidence.
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spelling pubmed-74643062020-09-04 Imaging Bacteria with Radiolabelled Probes: Is It Feasible? Signore, Alberto Artiko, Vera Conserva, Martina Ferro-Flores, Guillermina Welling, Mick M. Jain, Sanjay K. Hess, Søren Sathekge, Mike J Clin Med Conference Report Bacterial infections are the main cause of patient morbidity and mortality worldwide. Diagnosis can be difficult and delayed as well as the identification of the etiological pathogen, necessary for a tailored antibiotic therapy. Several non-invasive diagnostic procedures are available, all with pros and cons. Molecular nuclear medicine has highly contributed in this field by proposing several different radiopharmaceuticals (antimicrobial peptides, leukocytes, cytokines, antibiotics, sugars, etc.) but none proved to be highly specific for bacteria, although many agents in development look promising. Indeed, factors including the number and strain of bacteria, the infection site, and the host condition, may affect the specificity of the tested radiopharmaceuticals. At the Third European Congress on Infection/Inflammation Imaging, a round table discussion was dedicated to debate the pros and cons of different radiopharmaceuticals for imaging bacteria with the final goal to find a consensus on the most relevant research steps that should be fulfilled when testing a new probe, based on experience and cumulative published evidence. MDPI 2020-07-25 /pmc/articles/PMC7464306/ /pubmed/32722355 http://dx.doi.org/10.3390/jcm9082372 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Conference Report
Signore, Alberto
Artiko, Vera
Conserva, Martina
Ferro-Flores, Guillermina
Welling, Mick M.
Jain, Sanjay K.
Hess, Søren
Sathekge, Mike
Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title_full Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title_fullStr Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title_full_unstemmed Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title_short Imaging Bacteria with Radiolabelled Probes: Is It Feasible?
title_sort imaging bacteria with radiolabelled probes: is it feasible?
topic Conference Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464306/
https://www.ncbi.nlm.nih.gov/pubmed/32722355
http://dx.doi.org/10.3390/jcm9082372
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