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Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED
The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the lite...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464376/ https://www.ncbi.nlm.nih.gov/pubmed/32759793 http://dx.doi.org/10.3390/cancers12082166 |
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author | Chabay, Paola Lens, Daniela Hassan, Rocio Rodríguez Pinilla, Socorro María Valvert Gamboa, Fabiola Rivera, Iris Huamán Garaicoa, Fuad Ranuncolo, Stella Maris Barrionuevo, Carlos Morales Sánchez, Abigail Scholl, Vanesa De Matteo, Elena Preciado, Ma. Victoria Fuentes-Pananá, Ezequiel M. |
author_facet | Chabay, Paola Lens, Daniela Hassan, Rocio Rodríguez Pinilla, Socorro María Valvert Gamboa, Fabiola Rivera, Iris Huamán Garaicoa, Fuad Ranuncolo, Stella Maris Barrionuevo, Carlos Morales Sánchez, Abigail Scholl, Vanesa De Matteo, Elena Preciado, Ma. Victoria Fuentes-Pananá, Ezequiel M. |
author_sort | Chabay, Paola |
collection | PubMed |
description | The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations. |
format | Online Article Text |
id | pubmed-7464376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74643762020-09-04 Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED Chabay, Paola Lens, Daniela Hassan, Rocio Rodríguez Pinilla, Socorro María Valvert Gamboa, Fabiola Rivera, Iris Huamán Garaicoa, Fuad Ranuncolo, Stella Maris Barrionuevo, Carlos Morales Sánchez, Abigail Scholl, Vanesa De Matteo, Elena Preciado, Ma. Victoria Fuentes-Pananá, Ezequiel M. Cancers (Basel) Review The Epstein–Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e.g., Mexico and Peru, have a high incidence of EBV-positive lymphomas of T/NK cell origin. Peru also carries the highest frequency of EBV-positive classical Hodgkin lymphoma (HL) and EBV-positive diffuse large B cell lymphoma, not otherwise specified (NOS), than any other LA country. Adult T cell lymphoma is endemic to the North of Brazil and Chile. While only few cases of KSHV-positive lymphomas were found, in spite of the close correlation of Kaposi sarcoma and the prevalence of pathogenic types of KSHV. Both EBV-associated HL and Burkitt lymphoma mainly affect young children, unlike in developed countries, in which adolescents and young adults are the most affected, correlating with an early EBV seroconversion for LA population despite of lack of infectious mononucleosis symptoms. High endemicity of KSHV and HTLV infection was observed among Amerindian populations, with differences between Amazonian and Andean populations. MDPI 2020-08-04 /pmc/articles/PMC7464376/ /pubmed/32759793 http://dx.doi.org/10.3390/cancers12082166 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chabay, Paola Lens, Daniela Hassan, Rocio Rodríguez Pinilla, Socorro María Valvert Gamboa, Fabiola Rivera, Iris Huamán Garaicoa, Fuad Ranuncolo, Stella Maris Barrionuevo, Carlos Morales Sánchez, Abigail Scholl, Vanesa De Matteo, Elena Preciado, Ma. Victoria Fuentes-Pananá, Ezequiel M. Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title | Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title_full | Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title_fullStr | Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title_full_unstemmed | Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title_short | Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED |
title_sort | lymphotropic viruses ebv, kshv and htlv in latin america: epidemiology and associated malignancies. a literature-based study by the rial-cyted |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464376/ https://www.ncbi.nlm.nih.gov/pubmed/32759793 http://dx.doi.org/10.3390/cancers12082166 |
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