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Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling

Background. Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. Aim. We investigated the relationship between LVRR and sex and its long-term outcomes. Met...

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Autores principales: Cannata, Antonio, Manca, Paolo, Nuzzi, Vincenzo, Gregorio, Caterina, Artico, Jessica, Gentile, Piero, Pio Loco, Carola, Ramani, Federica, Barbati, Giulia, Merlo, Marco, Sinagra, Gianfranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464387/
https://www.ncbi.nlm.nih.gov/pubmed/32751220
http://dx.doi.org/10.3390/jcm9082426
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author Cannata, Antonio
Manca, Paolo
Nuzzi, Vincenzo
Gregorio, Caterina
Artico, Jessica
Gentile, Piero
Pio Loco, Carola
Ramani, Federica
Barbati, Giulia
Merlo, Marco
Sinagra, Gianfranco
author_facet Cannata, Antonio
Manca, Paolo
Nuzzi, Vincenzo
Gregorio, Caterina
Artico, Jessica
Gentile, Piero
Pio Loco, Carola
Ramani, Federica
Barbati, Giulia
Merlo, Marco
Sinagra, Gianfranco
author_sort Cannata, Antonio
collection PubMed
description Background. Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. Aim. We investigated the relationship between LVRR and sex and its long-term outcomes. Methods. A cohort of 605 DCM patients with available follow-up data was consecutively enrolled. LVRR was defined, at 24-month follow-up evaluation, as an increase in left ventricular ejection fraction (LVEF) ≥ 10% or a LVEF > 50% and a decrease ≥ 10% in indexed left ventricular end-diastolic diameter (LVEDDi) or an LVEDDi ≤ 33 mm/m(2). Outcome measures were a composite of all-cause mortality/heart transplantation (HTx) or ventricular assist device (VAD) and a composite of Sudden Cardiac Death (SCD) or Major Ventricular Arrhythmias (MVA). Results. 181 patients (30%) experienced LVRR. The cumulative incidence of LVRR at 24-months evaluation was comparable between sexes (33% vs. 29%; p = 0.26). During a median follow-up of 149 months, women experiencing LVRR had the lowest rate of main outcome measure (global p = 0.03) with a 71% relative risk reduction compared to men with LVRR, without significant difference between women without LVRR and males. A trend towards the same results was found regarding SCD/MVA (global p = 0.06). Applying a multi-state model, male sex emerged as an independent adverse prognostic factor even after LVRR completion. Conclusions. Although the rate of LVRR was comparable between sexes, females experiencing LVRR showed the best outcomes in the long term follow up compared to males and females without LVRR. Further studies are advocated to explain this difference in outcomes between sexes.
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spelling pubmed-74643872020-09-04 Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling Cannata, Antonio Manca, Paolo Nuzzi, Vincenzo Gregorio, Caterina Artico, Jessica Gentile, Piero Pio Loco, Carola Ramani, Federica Barbati, Giulia Merlo, Marco Sinagra, Gianfranco J Clin Med Article Background. Women affected by Dilated Cardiomyopathy (DCM) experience better outcomes compared to men. Whether a more pronounced Left Ventricular Reverse Remodelling (LVRR) might explain this is still unknown. Aim. We investigated the relationship between LVRR and sex and its long-term outcomes. Methods. A cohort of 605 DCM patients with available follow-up data was consecutively enrolled. LVRR was defined, at 24-month follow-up evaluation, as an increase in left ventricular ejection fraction (LVEF) ≥ 10% or a LVEF > 50% and a decrease ≥ 10% in indexed left ventricular end-diastolic diameter (LVEDDi) or an LVEDDi ≤ 33 mm/m(2). Outcome measures were a composite of all-cause mortality/heart transplantation (HTx) or ventricular assist device (VAD) and a composite of Sudden Cardiac Death (SCD) or Major Ventricular Arrhythmias (MVA). Results. 181 patients (30%) experienced LVRR. The cumulative incidence of LVRR at 24-months evaluation was comparable between sexes (33% vs. 29%; p = 0.26). During a median follow-up of 149 months, women experiencing LVRR had the lowest rate of main outcome measure (global p = 0.03) with a 71% relative risk reduction compared to men with LVRR, without significant difference between women without LVRR and males. A trend towards the same results was found regarding SCD/MVA (global p = 0.06). Applying a multi-state model, male sex emerged as an independent adverse prognostic factor even after LVRR completion. Conclusions. Although the rate of LVRR was comparable between sexes, females experiencing LVRR showed the best outcomes in the long term follow up compared to males and females without LVRR. Further studies are advocated to explain this difference in outcomes between sexes. MDPI 2020-07-29 /pmc/articles/PMC7464387/ /pubmed/32751220 http://dx.doi.org/10.3390/jcm9082426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cannata, Antonio
Manca, Paolo
Nuzzi, Vincenzo
Gregorio, Caterina
Artico, Jessica
Gentile, Piero
Pio Loco, Carola
Ramani, Federica
Barbati, Giulia
Merlo, Marco
Sinagra, Gianfranco
Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title_full Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title_fullStr Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title_full_unstemmed Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title_short Sex-Specific Prognostic Implications in Dilated Cardiomyopathy After Left Ventricular Reverse Remodeling
title_sort sex-specific prognostic implications in dilated cardiomyopathy after left ventricular reverse remodeling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464387/
https://www.ncbi.nlm.nih.gov/pubmed/32751220
http://dx.doi.org/10.3390/jcm9082426
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