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Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity

Background: The presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia and frailty remains unknown. Methods: Multicentric prospective observational study in order to assess oxidative stress markers (catalase, glutathione reductase (GR), tot...

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Autores principales: Bernabeu-Wittel, Máximo, Gómez-Díaz, Raquel, González-Molina, Álvaro, Vidal-Serrano, Sofía, Díez-Manglano, Jesús, Salgado, Fernando, Soto-Martín, María, Ollero-Baturone, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464426/
https://www.ncbi.nlm.nih.gov/pubmed/32824789
http://dx.doi.org/10.3390/jcm9082669
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author Bernabeu-Wittel, Máximo
Gómez-Díaz, Raquel
González-Molina, Álvaro
Vidal-Serrano, Sofía
Díez-Manglano, Jesús
Salgado, Fernando
Soto-Martín, María
Ollero-Baturone, Manuel
author_facet Bernabeu-Wittel, Máximo
Gómez-Díaz, Raquel
González-Molina, Álvaro
Vidal-Serrano, Sofía
Díez-Manglano, Jesús
Salgado, Fernando
Soto-Martín, María
Ollero-Baturone, Manuel
author_sort Bernabeu-Wittel, Máximo
collection PubMed
description Background: The presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia and frailty remains unknown. Methods: Multicentric prospective observational study in order to assess oxidative stress markers (catalase, glutathione reductase (GR), total antioxidant capacity to reactive oxygen species (TAC-ROS), and superoxide dismutase (SOD)), absolute telomere length (aTL), and apoptosis (DNA fragmentation) in peripheral blood samples of a hospital-based population of PP. Associations of these biomarkers to sarcopenia, frailty, functional status, and 12-month mortality were analyzed. Results: Of the 444 recruited patients, 97 (21.8%), 278 (62.6%), and 80 (18%) were sarcopenic, frail, or both, respectively. Oxidative stress markers (lower TAC-ROS and higher SOD) were significantly enhanced and aTL significantly shortened in patients with sarcopenia, frailty or both syndromes. No evidence of apoptosis was detected in blood leukocytes of any of the patients. Both oxidative stress markers (GR, p = 0.04) and telomere shortening (p = 0.001) were associated to death risk and to less survival days. Conclusions: Oxidative stress markers and telomere length were enhanced and shortened, respectively, in blood samples of polypathological patients with sarcopenia and/or frailty. Both were associated to decreased survival. They could be useful in the clinical practice to assess vulnerable populations with multimorbidity and of potential interest as therapeutic targets.
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spelling pubmed-74644262020-09-04 Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity Bernabeu-Wittel, Máximo Gómez-Díaz, Raquel González-Molina, Álvaro Vidal-Serrano, Sofía Díez-Manglano, Jesús Salgado, Fernando Soto-Martín, María Ollero-Baturone, Manuel J Clin Med Article Background: The presence of oxidative stress, telomere shortening, and apoptosis in polypathological patients (PP) with sarcopenia and frailty remains unknown. Methods: Multicentric prospective observational study in order to assess oxidative stress markers (catalase, glutathione reductase (GR), total antioxidant capacity to reactive oxygen species (TAC-ROS), and superoxide dismutase (SOD)), absolute telomere length (aTL), and apoptosis (DNA fragmentation) in peripheral blood samples of a hospital-based population of PP. Associations of these biomarkers to sarcopenia, frailty, functional status, and 12-month mortality were analyzed. Results: Of the 444 recruited patients, 97 (21.8%), 278 (62.6%), and 80 (18%) were sarcopenic, frail, or both, respectively. Oxidative stress markers (lower TAC-ROS and higher SOD) were significantly enhanced and aTL significantly shortened in patients with sarcopenia, frailty or both syndromes. No evidence of apoptosis was detected in blood leukocytes of any of the patients. Both oxidative stress markers (GR, p = 0.04) and telomere shortening (p = 0.001) were associated to death risk and to less survival days. Conclusions: Oxidative stress markers and telomere length were enhanced and shortened, respectively, in blood samples of polypathological patients with sarcopenia and/or frailty. Both were associated to decreased survival. They could be useful in the clinical practice to assess vulnerable populations with multimorbidity and of potential interest as therapeutic targets. MDPI 2020-08-18 /pmc/articles/PMC7464426/ /pubmed/32824789 http://dx.doi.org/10.3390/jcm9082669 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bernabeu-Wittel, Máximo
Gómez-Díaz, Raquel
González-Molina, Álvaro
Vidal-Serrano, Sofía
Díez-Manglano, Jesús
Salgado, Fernando
Soto-Martín, María
Ollero-Baturone, Manuel
Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title_full Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title_fullStr Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title_full_unstemmed Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title_short Oxidative Stress, Telomere Shortening, and Apoptosis Associated to Sarcopenia and Frailty in Patients with Multimorbidity
title_sort oxidative stress, telomere shortening, and apoptosis associated to sarcopenia and frailty in patients with multimorbidity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464426/
https://www.ncbi.nlm.nih.gov/pubmed/32824789
http://dx.doi.org/10.3390/jcm9082669
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