Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing adjacent to each active site of a NAMPT homodim...

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Detalles Bibliográficos
Autores principales: Tanuma, Sei-ichi, Katsuragi, Kiyotaka, Oyama, Takahiro, Yoshimori, Atsushi, Shibasaki, Yuri, Asawa, Yasunobu, Yamazaki, Hiroaki, Makino, Kosho, Okazawa, Miwa, Ogino, Yoko, Sakamoto, Yoshimi, Nomura, Miyuki, Sato, Akira, Abe, Hideaki, Nakamura, Hiroyuki, Takahashi, Hideyo, Tanuma, Nobuhiro, Uchiumi, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464552/
https://www.ncbi.nlm.nih.gov/pubmed/32785052
http://dx.doi.org/10.3390/molecules25163633

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