Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of fluconazole (FLC) by replacing one of its two triazole moieties by an indole scaffold. Two different chemical approaches were then developed. The first one, in seven steps, involved the synthesis of the key intermediat...

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Detalles Bibliográficos
Autores principales: Lebouvier, Nicolas, Pagniez, Fabrice, Na, Young Min, Shi, Da, Pinson, Patricia, Marchivie, Mathieu, Guillon, Jean, Hakki, Tarek, Bernhardt, Rita, Yee, Sook Wah, Simons, Claire, Lézé, Marie-Pierre, Hartmann, Rolf W., Mularoni, Angélique, Le Baut, Guillaume, Krimm, Isabelle, Abagyan, Ruben, Le Pape, Patrice, Le Borgne, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464559/
https://www.ncbi.nlm.nih.gov/pubmed/32784450
http://dx.doi.org/10.3390/ph13080186

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