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Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties

Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents i...

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Autores principales: Zapata, Mayra Eliana Valencia, Ruiz Rojas, Lina Marcela, Mina Hernández, José Herminsul, Delgado-Ospina, Johannes, Tovar, Carlos David Grande
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464601/
https://www.ncbi.nlm.nih.gov/pubmed/32784747
http://dx.doi.org/10.3390/polym12081773
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author Zapata, Mayra Eliana Valencia
Ruiz Rojas, Lina Marcela
Mina Hernández, José Herminsul
Delgado-Ospina, Johannes
Tovar, Carlos David Grande
author_facet Zapata, Mayra Eliana Valencia
Ruiz Rojas, Lina Marcela
Mina Hernández, José Herminsul
Delgado-Ospina, Johannes
Tovar, Carlos David Grande
author_sort Zapata, Mayra Eliana Valencia
collection PubMed
description Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents in acrylic bone cements (ABCs) is open. In this study, the antibacterial effect of formulations of ABCs loaded with graphene oxide (GO) between 0 and 0.5 wt.% was evaluated against Gram-positive bacteria: Bacillus cereus and Staphylococcus aureus, and Gram-negative ones: Salmonella enterica and Escherichia coli. It was found that the effect of GO was dependent on the concentration and type of bacteria: GO loadings ≥0.2 wt.% presented total inhibition of Gram-negative bacteria, while GO loadings ≥0.3 wt.% was necessary to achieve the same effect with Gram-positives bacteria. Additionally, the evaluation of some physical and mechanical properties showed that the presence of GO in cement formulations increased wettability by 17%, reduced maximum temperature during polymerization by 19%, increased setting time by 40%, and increased compressive and flexural mechanical properties by up to 17%, all of which are desirable behaviors in ABCs. The formulation of ABC loading with 0.3 wt.% GO showed great potential for use as a bone cement with antibacterial properties.
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spelling pubmed-74646012020-09-04 Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties Zapata, Mayra Eliana Valencia Ruiz Rojas, Lina Marcela Mina Hernández, José Herminsul Delgado-Ospina, Johannes Tovar, Carlos David Grande Polymers (Basel) Article Bacterial infections are a common complication after total joint replacements (TJRs), the treatment of which is usually based on the application of antibiotic-loaded cements; however, owing to the increase in antibiotic-resistant microorganisms, the possibility of studying new antibacterial agents in acrylic bone cements (ABCs) is open. In this study, the antibacterial effect of formulations of ABCs loaded with graphene oxide (GO) between 0 and 0.5 wt.% was evaluated against Gram-positive bacteria: Bacillus cereus and Staphylococcus aureus, and Gram-negative ones: Salmonella enterica and Escherichia coli. It was found that the effect of GO was dependent on the concentration and type of bacteria: GO loadings ≥0.2 wt.% presented total inhibition of Gram-negative bacteria, while GO loadings ≥0.3 wt.% was necessary to achieve the same effect with Gram-positives bacteria. Additionally, the evaluation of some physical and mechanical properties showed that the presence of GO in cement formulations increased wettability by 17%, reduced maximum temperature during polymerization by 19%, increased setting time by 40%, and increased compressive and flexural mechanical properties by up to 17%, all of which are desirable behaviors in ABCs. The formulation of ABC loading with 0.3 wt.% GO showed great potential for use as a bone cement with antibacterial properties. MDPI 2020-08-07 /pmc/articles/PMC7464601/ /pubmed/32784747 http://dx.doi.org/10.3390/polym12081773 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zapata, Mayra Eliana Valencia
Ruiz Rojas, Lina Marcela
Mina Hernández, José Herminsul
Delgado-Ospina, Johannes
Tovar, Carlos David Grande
Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_full Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_fullStr Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_full_unstemmed Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_short Acrylic Bone Cements Modified with Graphene Oxide: Mechanical, Physical, and Antibacterial Properties
title_sort acrylic bone cements modified with graphene oxide: mechanical, physical, and antibacterial properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464601/
https://www.ncbi.nlm.nih.gov/pubmed/32784747
http://dx.doi.org/10.3390/polym12081773
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