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Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can prov...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464633/ https://www.ncbi.nlm.nih.gov/pubmed/32785171 http://dx.doi.org/10.3390/pharmaceutics12080752 |
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author | Carballo-Pedrares, Natalia Fuentes-Boquete, Isaac Díaz-Prado, Silvia Rey-Rico, Ana |
author_facet | Carballo-Pedrares, Natalia Fuentes-Boquete, Isaac Díaz-Prado, Silvia Rey-Rico, Ana |
author_sort | Carballo-Pedrares, Natalia |
collection | PubMed |
description | Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches. |
format | Online Article Text |
id | pubmed-7464633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74646332020-09-04 Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview Carballo-Pedrares, Natalia Fuentes-Boquete, Isaac Díaz-Prado, Silvia Rey-Rico, Ana Pharmaceutics Review Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches. MDPI 2020-08-10 /pmc/articles/PMC7464633/ /pubmed/32785171 http://dx.doi.org/10.3390/pharmaceutics12080752 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carballo-Pedrares, Natalia Fuentes-Boquete, Isaac Díaz-Prado, Silvia Rey-Rico, Ana Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title | Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title_full | Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title_fullStr | Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title_full_unstemmed | Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title_short | Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview |
title_sort | hydrogel-based localized nonviral gene delivery in regenerative medicine approaches—an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464633/ https://www.ncbi.nlm.nih.gov/pubmed/32785171 http://dx.doi.org/10.3390/pharmaceutics12080752 |
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