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Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview

Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can prov...

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Detalles Bibliográficos
Autores principales: Carballo-Pedrares, Natalia, Fuentes-Boquete, Isaac, Díaz-Prado, Silvia, Rey-Rico, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464633/
https://www.ncbi.nlm.nih.gov/pubmed/32785171
http://dx.doi.org/10.3390/pharmaceutics12080752
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author Carballo-Pedrares, Natalia
Fuentes-Boquete, Isaac
Díaz-Prado, Silvia
Rey-Rico, Ana
author_facet Carballo-Pedrares, Natalia
Fuentes-Boquete, Isaac
Díaz-Prado, Silvia
Rey-Rico, Ana
author_sort Carballo-Pedrares, Natalia
collection PubMed
description Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches.
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spelling pubmed-74646332020-09-04 Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview Carballo-Pedrares, Natalia Fuentes-Boquete, Isaac Díaz-Prado, Silvia Rey-Rico, Ana Pharmaceutics Review Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches. MDPI 2020-08-10 /pmc/articles/PMC7464633/ /pubmed/32785171 http://dx.doi.org/10.3390/pharmaceutics12080752 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carballo-Pedrares, Natalia
Fuentes-Boquete, Isaac
Díaz-Prado, Silvia
Rey-Rico, Ana
Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title_full Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title_fullStr Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title_full_unstemmed Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title_short Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview
title_sort hydrogel-based localized nonviral gene delivery in regenerative medicine approaches—an overview
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464633/
https://www.ncbi.nlm.nih.gov/pubmed/32785171
http://dx.doi.org/10.3390/pharmaceutics12080752
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