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Antioxidant Activity of Synthetic Polymers of Phenolic Compounds
In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polym...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464737/ https://www.ncbi.nlm.nih.gov/pubmed/32722059 http://dx.doi.org/10.3390/polym12081646 |
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author | Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Salemme, Adele Togna, Anna Rita Saso, Luciano Bruno, Ferdinando |
author_facet | Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Salemme, Adele Togna, Anna Rita Saso, Luciano Bruno, Ferdinando |
author_sort | Nagarajan, Subhalakshmi |
collection | PubMed |
description | In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polymeric phenols have received much attention owing to their potent antioxidant properties and increased stability in aqueous systems. To be truly effective in biological applications, it is important that these polymers be synthesized using benign methods. In this context, enzyme catalyzed synthesis of polymeric phenols has been explored as an environmentally friendly and safer approach. This review summarizes work in enzymatic syntheses of polymers of phenols. Several assays have been developed to determine the antioxidant potency of these polymeric phenols. These assays are discussed in detail along with structure-property relationships. A deeper understanding of factors affecting antioxidant activity would provide an opportunity for the design of versatile, high performing polymers with enhanced antioxidant activity. |
format | Online Article Text |
id | pubmed-7464737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74647372020-09-04 Antioxidant Activity of Synthetic Polymers of Phenolic Compounds Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Salemme, Adele Togna, Anna Rita Saso, Luciano Bruno, Ferdinando Polymers (Basel) Review In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polymeric phenols have received much attention owing to their potent antioxidant properties and increased stability in aqueous systems. To be truly effective in biological applications, it is important that these polymers be synthesized using benign methods. In this context, enzyme catalyzed synthesis of polymeric phenols has been explored as an environmentally friendly and safer approach. This review summarizes work in enzymatic syntheses of polymers of phenols. Several assays have been developed to determine the antioxidant potency of these polymeric phenols. These assays are discussed in detail along with structure-property relationships. A deeper understanding of factors affecting antioxidant activity would provide an opportunity for the design of versatile, high performing polymers with enhanced antioxidant activity. MDPI 2020-07-24 /pmc/articles/PMC7464737/ /pubmed/32722059 http://dx.doi.org/10.3390/polym12081646 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nagarajan, Subhalakshmi Nagarajan, Ramaswamy Kumar, Jayant Salemme, Adele Togna, Anna Rita Saso, Luciano Bruno, Ferdinando Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title | Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title_full | Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title_fullStr | Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title_full_unstemmed | Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title_short | Antioxidant Activity of Synthetic Polymers of Phenolic Compounds |
title_sort | antioxidant activity of synthetic polymers of phenolic compounds |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464737/ https://www.ncbi.nlm.nih.gov/pubmed/32722059 http://dx.doi.org/10.3390/polym12081646 |
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