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Profound Reprogramming towards Stemness in Pancreatic Cancer Cells as Adaptation to AKT Inhibition

Cancer cells acquire resistance to cytotoxic therapies targeting major survival pathways by adapting their metabolism. The AKT pathway is a major regulator of human pancreatic adenocarcinoma progression and a key pharmacological target. The mechanisms of adaptation to long-term silencing of AKT isof...

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Detalles Bibliográficos
Autores principales:	Arasanz, Hugo, Hernández, Carlos, Bocanegra, Ana, Chocarro, Luisa, Zuazo, Miren, Gato, Maria, Ausin, Karina, Santamaría, Enrique, Fernández-Irigoyen, Joaquín, Fernandez, Gonzalo, Santamaria, Eva, Rodríguez, Carlos, Blanco-Luquin, Idoia, Vera, Ruth, Escors, David, Kochan, Grazyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464748/ https://www.ncbi.nlm.nih.gov/pubmed/32764385 http://dx.doi.org/10.3390/cancers12082181

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