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Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial

Introduction: Myxoid liposarcoma (MLPS) has been reported to be more radiosensitive compared with other soft tissue sarcomas. The main objective of the study was to assess the efficacy of hypofractionated radiotherapy (RT) in the preoperative setting in patients with locally advanced primary MLPS. M...

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Autores principales: Koseła-Paterczyk, Hanna, Spałek, Mateusz, Borkowska, Aneta, Teterycz, Paweł, Wągrodzki, Michał, Szumera-Ciećkiewicz, Anna, Morysiński, Tadeusz, Castaneda-Wysocka, Patrycja, Cieszanowski, Andrzej, Zdzienicki, Marcin, Goryń, Tomasz, Rutkowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464815/
https://www.ncbi.nlm.nih.gov/pubmed/32752185
http://dx.doi.org/10.3390/jcm9082471
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author Koseła-Paterczyk, Hanna
Spałek, Mateusz
Borkowska, Aneta
Teterycz, Paweł
Wągrodzki, Michał
Szumera-Ciećkiewicz, Anna
Morysiński, Tadeusz
Castaneda-Wysocka, Patrycja
Cieszanowski, Andrzej
Zdzienicki, Marcin
Goryń, Tomasz
Rutkowski, Piotr
author_facet Koseła-Paterczyk, Hanna
Spałek, Mateusz
Borkowska, Aneta
Teterycz, Paweł
Wągrodzki, Michał
Szumera-Ciećkiewicz, Anna
Morysiński, Tadeusz
Castaneda-Wysocka, Patrycja
Cieszanowski, Andrzej
Zdzienicki, Marcin
Goryń, Tomasz
Rutkowski, Piotr
author_sort Koseła-Paterczyk, Hanna
collection PubMed
description Introduction: Myxoid liposarcoma (MLPS) has been reported to be more radiosensitive compared with other soft tissue sarcomas. The main objective of the study was to assess the efficacy of hypofractionated radiotherapy (RT) in the preoperative setting in patients with locally advanced primary MLPS. Methods: Single-arm prospective exploratory clinical trial enrolled MLPS patients for preoperative 5 × 5 Gy RT with delayed surgery. The endpoints of the study were the rate of early wound healing complications and 5-year local control rate. Results: 29 patients (pts) were included, all had tumors located on the lower limb. The median maximum size of the tumor was 13 cm (IQR 10–15 cm). Early RT tolerance was good. Postoperative wound complications occurred in 11 pts (37.9%), late complications concerned 13.8% of patients. A total of 27 patients were included for the efficacy analyses. The pathological features of response to RT were detected in all analyzed surgical specimens. In 25 patients R0 margins were achieved, two patients had an R1 resection. None of the patients had local recurrence. Conclusion: Preoperative hypofractionated RT with a prolonged gap between RT and surgery is a feasible method of the management of MLPS, providing a good local control and low rates of treatment toxicity.
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spelling pubmed-74648152020-09-04 Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial Koseła-Paterczyk, Hanna Spałek, Mateusz Borkowska, Aneta Teterycz, Paweł Wągrodzki, Michał Szumera-Ciećkiewicz, Anna Morysiński, Tadeusz Castaneda-Wysocka, Patrycja Cieszanowski, Andrzej Zdzienicki, Marcin Goryń, Tomasz Rutkowski, Piotr J Clin Med Article Introduction: Myxoid liposarcoma (MLPS) has been reported to be more radiosensitive compared with other soft tissue sarcomas. The main objective of the study was to assess the efficacy of hypofractionated radiotherapy (RT) in the preoperative setting in patients with locally advanced primary MLPS. Methods: Single-arm prospective exploratory clinical trial enrolled MLPS patients for preoperative 5 × 5 Gy RT with delayed surgery. The endpoints of the study were the rate of early wound healing complications and 5-year local control rate. Results: 29 patients (pts) were included, all had tumors located on the lower limb. The median maximum size of the tumor was 13 cm (IQR 10–15 cm). Early RT tolerance was good. Postoperative wound complications occurred in 11 pts (37.9%), late complications concerned 13.8% of patients. A total of 27 patients were included for the efficacy analyses. The pathological features of response to RT were detected in all analyzed surgical specimens. In 25 patients R0 margins were achieved, two patients had an R1 resection. None of the patients had local recurrence. Conclusion: Preoperative hypofractionated RT with a prolonged gap between RT and surgery is a feasible method of the management of MLPS, providing a good local control and low rates of treatment toxicity. MDPI 2020-08-01 /pmc/articles/PMC7464815/ /pubmed/32752185 http://dx.doi.org/10.3390/jcm9082471 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koseła-Paterczyk, Hanna
Spałek, Mateusz
Borkowska, Aneta
Teterycz, Paweł
Wągrodzki, Michał
Szumera-Ciećkiewicz, Anna
Morysiński, Tadeusz
Castaneda-Wysocka, Patrycja
Cieszanowski, Andrzej
Zdzienicki, Marcin
Goryń, Tomasz
Rutkowski, Piotr
Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title_full Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title_fullStr Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title_full_unstemmed Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title_short Hypofractionated Radiotherapy in Locally Advanced Myxoid Liposarcomas of Extremities or Trunk Wall: Results of a Single-Arm Prospective Clinical Trial
title_sort hypofractionated radiotherapy in locally advanced myxoid liposarcomas of extremities or trunk wall: results of a single-arm prospective clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464815/
https://www.ncbi.nlm.nih.gov/pubmed/32752185
http://dx.doi.org/10.3390/jcm9082471
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