Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei

We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamas...

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Detalles Bibliográficos
Autores principales: Siméon, Soline, Dortet, Laurent, Bouchand, Frédérique, Roux, Anne-Laure, Bonnin, Rémy A., Duran, Clara, Decousser, Jean-Winoc, Bessis, Simon, Davido, Benjamin, Sorriaux, Grégory, Dinh, Aurélien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464826/
https://www.ncbi.nlm.nih.gov/pubmed/32823796
http://dx.doi.org/10.3390/microorganisms8081236
Descripción
Sumario:We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome.

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