Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei

We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamas...

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Autores principales: Siméon, Soline, Dortet, Laurent, Bouchand, Frédérique, Roux, Anne-Laure, Bonnin, Rémy A., Duran, Clara, Decousser, Jean-Winoc, Bessis, Simon, Davido, Benjamin, Sorriaux, Grégory, Dinh, Aurélien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464826/
https://www.ncbi.nlm.nih.gov/pubmed/32823796
http://dx.doi.org/10.3390/microorganisms8081236
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author Siméon, Soline
Dortet, Laurent
Bouchand, Frédérique
Roux, Anne-Laure
Bonnin, Rémy A.
Duran, Clara
Decousser, Jean-Winoc
Bessis, Simon
Davido, Benjamin
Sorriaux, Grégory
Dinh, Aurélien
author_facet Siméon, Soline
Dortet, Laurent
Bouchand, Frédérique
Roux, Anne-Laure
Bonnin, Rémy A.
Duran, Clara
Decousser, Jean-Winoc
Bessis, Simon
Davido, Benjamin
Sorriaux, Grégory
Dinh, Aurélien
author_sort Siméon, Soline
collection PubMed
description We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome.
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spelling pubmed-74648262020-09-04 Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei Siméon, Soline Dortet, Laurent Bouchand, Frédérique Roux, Anne-Laure Bonnin, Rémy A. Duran, Clara Decousser, Jean-Winoc Bessis, Simon Davido, Benjamin Sorriaux, Grégory Dinh, Aurélien Microorganisms Case Report We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome. MDPI 2020-08-13 /pmc/articles/PMC7464826/ /pubmed/32823796 http://dx.doi.org/10.3390/microorganisms8081236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Siméon, Soline
Dortet, Laurent
Bouchand, Frédérique
Roux, Anne-Laure
Bonnin, Rémy A.
Duran, Clara
Decousser, Jean-Winoc
Bessis, Simon
Davido, Benjamin
Sorriaux, Grégory
Dinh, Aurélien
Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title_full Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title_fullStr Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title_full_unstemmed Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title_short Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant Enterobacter hormaechei
title_sort compassionate use of cefiderocol to treat a case of prosthetic joint infection due to extensively drug-resistant enterobacter hormaechei
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464826/
https://www.ncbi.nlm.nih.gov/pubmed/32823796
http://dx.doi.org/10.3390/microorganisms8081236
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