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Association between African Dust Transport and Acute Exacerbations of COPD in Miami

Background: Air pollution is increasingly recognized as a risk factor for acute exacerbation of chronic obstructive pulmonary disease (COPD). Changing climate and weather patterns can modify the levels and types of air pollutants. For example, dust outbreaks increase particulate air pollution. Objec...

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Autores principales: Gutierrez, Miguel Pardinas, Zuidema, Paquita, Mirsaeidi, Mehdi, Campos, Michael, Kumar, Naresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464868/
https://www.ncbi.nlm.nih.gov/pubmed/32756441
http://dx.doi.org/10.3390/jcm9082496
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author Gutierrez, Miguel Pardinas
Zuidema, Paquita
Mirsaeidi, Mehdi
Campos, Michael
Kumar, Naresh
author_facet Gutierrez, Miguel Pardinas
Zuidema, Paquita
Mirsaeidi, Mehdi
Campos, Michael
Kumar, Naresh
author_sort Gutierrez, Miguel Pardinas
collection PubMed
description Background: Air pollution is increasingly recognized as a risk factor for acute exacerbation of chronic obstructive pulmonary disease (COPD). Changing climate and weather patterns can modify the levels and types of air pollutants. For example, dust outbreaks increase particulate air pollution. Objective: This paper examines the effect of Saharan dust storms on the concentration of coarse particulate matter in Miami, and its association with the risk of acute exacerbation of COPD (AECOPD). Methods: In this prospective cohort study, 296 COPD patients (with 313 events) were followed between 2013 and 2016. We used Light Detection and Ranging (LIDAR) and satellite-based Aerosol Optical Depth (AOD) to identify dust events and quantify particulate matter (PM) exposure, respectively. Exacerbation events were modeled with respect to location- and time-lagged dust and PM exposures, using multivariate logistic regressions. Measurements and main results: Dust duration and intensity increased yearly during the study period. During dust events, AOD increased by 51% and particulate matter ≤2.5 µm in aerodynamic diameter (PM(2.5)) increased by 25%. Adjusting for confounders, ambient temperature and local PM(2.5) exposure, one-day lagged dust exposure was associated with 4.9 times higher odds of two or more (2+ hereto after) AECOPD events (odds ratio = 4.9; 95% CI = 1.8–13.4; p < 0.001). Ambient temperature exposure also showed a significant association with 2+ and 3+ AECOPD events. The risk of AECOPD lasted up to 15 days after dust exposure, declining from 10× higher on day 0 to 20% higher on day 15. Conclusions: Saharan dust outbreaks observed in Miami elevate the concentration of PM and increase the risk of AECOPD in COPD patients with recurring exacerbations.
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spelling pubmed-74648682020-09-04 Association between African Dust Transport and Acute Exacerbations of COPD in Miami Gutierrez, Miguel Pardinas Zuidema, Paquita Mirsaeidi, Mehdi Campos, Michael Kumar, Naresh J Clin Med Article Background: Air pollution is increasingly recognized as a risk factor for acute exacerbation of chronic obstructive pulmonary disease (COPD). Changing climate and weather patterns can modify the levels and types of air pollutants. For example, dust outbreaks increase particulate air pollution. Objective: This paper examines the effect of Saharan dust storms on the concentration of coarse particulate matter in Miami, and its association with the risk of acute exacerbation of COPD (AECOPD). Methods: In this prospective cohort study, 296 COPD patients (with 313 events) were followed between 2013 and 2016. We used Light Detection and Ranging (LIDAR) and satellite-based Aerosol Optical Depth (AOD) to identify dust events and quantify particulate matter (PM) exposure, respectively. Exacerbation events were modeled with respect to location- and time-lagged dust and PM exposures, using multivariate logistic regressions. Measurements and main results: Dust duration and intensity increased yearly during the study period. During dust events, AOD increased by 51% and particulate matter ≤2.5 µm in aerodynamic diameter (PM(2.5)) increased by 25%. Adjusting for confounders, ambient temperature and local PM(2.5) exposure, one-day lagged dust exposure was associated with 4.9 times higher odds of two or more (2+ hereto after) AECOPD events (odds ratio = 4.9; 95% CI = 1.8–13.4; p < 0.001). Ambient temperature exposure also showed a significant association with 2+ and 3+ AECOPD events. The risk of AECOPD lasted up to 15 days after dust exposure, declining from 10× higher on day 0 to 20% higher on day 15. Conclusions: Saharan dust outbreaks observed in Miami elevate the concentration of PM and increase the risk of AECOPD in COPD patients with recurring exacerbations. MDPI 2020-08-03 /pmc/articles/PMC7464868/ /pubmed/32756441 http://dx.doi.org/10.3390/jcm9082496 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gutierrez, Miguel Pardinas
Zuidema, Paquita
Mirsaeidi, Mehdi
Campos, Michael
Kumar, Naresh
Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title_full Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title_fullStr Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title_full_unstemmed Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title_short Association between African Dust Transport and Acute Exacerbations of COPD in Miami
title_sort association between african dust transport and acute exacerbations of copd in miami
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464868/
https://www.ncbi.nlm.nih.gov/pubmed/32756441
http://dx.doi.org/10.3390/jcm9082496
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