Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We repurpose echinomycin, an antibiotic encapsulated within a syndecan-1 active...

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Detalles Bibliográficos
Autores principales: Thomas, Alexandra, Samykutty, Abhilash, Gomez-Gutierrez, Jorge G., Yin, Wenyuan, Egger, Michael E., McNally, Molly, Chuong, Phillip, MacCuaig, William M., Albeituni, Sabrin, Zeiderman, Matthew, Li, Min, Edil, Barish H., Grizzle, William E., McMasters, Kelly M., McNally, Lacey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464900/
https://www.ncbi.nlm.nih.gov/pubmed/32823919
http://dx.doi.org/10.3390/cancers12082279

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