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TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis
Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathoph...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464905/ https://www.ncbi.nlm.nih.gov/pubmed/32824669 http://dx.doi.org/10.3390/antiox9080765 |
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author | Yoshihara, Eiji |
author_facet | Yoshihara, Eiji |
author_sort | Yoshihara, Eiji |
collection | PubMed |
description | Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathophysiology. Due to the reducing activity of TRX, the TRX/TXNIP signal complex has been shown to be an important regulator for redox-related signal transduction in many types of cells in various species. In addition to its role in redox-dependent regulation, TXNIP has cellular functions that are performed in a redox-independent manner, which largely rely on their scaffolding function as an ancestral α-Arrestin family. Both the redox-dependent and -independent TXNIP functions serve as regulatory pathways in glucose metabolism. This review highlights the key advances in understanding TXNIP function as a master regulator for whole-body glucose homeostasis. The potential for therapeutic advantages of targeting TXNIP in diabetes and the future direction of the study are also discussed. |
format | Online Article Text |
id | pubmed-7464905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74649052020-09-04 TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis Yoshihara, Eiji Antioxidants (Basel) Review Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathophysiology. Due to the reducing activity of TRX, the TRX/TXNIP signal complex has been shown to be an important regulator for redox-related signal transduction in many types of cells in various species. In addition to its role in redox-dependent regulation, TXNIP has cellular functions that are performed in a redox-independent manner, which largely rely on their scaffolding function as an ancestral α-Arrestin family. Both the redox-dependent and -independent TXNIP functions serve as regulatory pathways in glucose metabolism. This review highlights the key advances in understanding TXNIP function as a master regulator for whole-body glucose homeostasis. The potential for therapeutic advantages of targeting TXNIP in diabetes and the future direction of the study are also discussed. MDPI 2020-08-18 /pmc/articles/PMC7464905/ /pubmed/32824669 http://dx.doi.org/10.3390/antiox9080765 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yoshihara, Eiji TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title | TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title_full | TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title_fullStr | TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title_full_unstemmed | TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title_short | TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis |
title_sort | txnip/tbp-2: a master regulator for glucose homeostasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464905/ https://www.ncbi.nlm.nih.gov/pubmed/32824669 http://dx.doi.org/10.3390/antiox9080765 |
work_keys_str_mv | AT yoshiharaeiji txniptbp2amasterregulatorforglucosehomeostasis |