Cargando…

Isolation of Antidiabetic Withanolides from Withania coagulans Dunal and Their In Vitro and In Silico Validation

Withania coagulans (W. coagulans) is well-known in herbal medicinal systems for its high biological potential. Different parts of the plant are used against insomnia, liver complications, asthma, and biliousness, as well as it is reported to be sedative, emetic, diuretic, antidiabetic antimicrobial,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maher, Saima, Choudhary, M. Iqbal, Saleem, Farooq, Rasheed, Saima, Waheed, Imran, Halim, Sobia Ahsan, Azeem, Muhammad, Abdullah, Iskandar Bin, Froeyen, Matheus, Mirza, Muhammad Usman, Ahmad, Sarfraz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464911/ https://www.ncbi.nlm.nih.gov/pubmed/32751610 http://dx.doi.org/10.3390/biology9080197

Ejemplares similares

Antidiabetic and antihyperlipidemic activity of hydroalcoholic extract of Withania coagulans Dunal dried fruit in experimental rat models
por: Datta, Ankur, et al.
Publicado: (2013)

Short term UV-B radiation mediated modulation of physiological traits and withanolides production in Withania coagulans (L.) Dunal under in-vitro condition
por: Tripathi, Deepika, et al.
Publicado: (2021)

Agrobacterium-Mediated Genetic Transformation of Withania coagulans (Dunal) with rol A Genes and Its Antioxidant Potential
por: Rehman, Samiya, et al.
Publicado: (2023)

Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal
por: Thorat, Sachin Ashok, et al.
Publicado: (2022)

Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice
por: Dey, Amitabha, et al.
Publicado: (2018)

A Decade of Molecular Understanding of Withanolide Biosynthesis and In vitro Studies in Withania somnifera (L.) Dunal: Prospects and Perspectives for Pathway Engineering
por: Dhar, Niha, et al.
Publicado: (2015)

Estimating the production of withaferin A and withanolide A in Withania somnifera (L.) dunal using aquaponics for sustainable development in hill agriculture
por: Singh, Manali, et al.
Publicado: (2023)

Withania Coagulans and Somnifera
por: Verghese, M.
Publicado: (1885)

Evaluation of the Antidiabetic Potential of an Isolated Hydroalcoholic Fraction from the Fruit of Withania coagulans
por: Waris, Md., et al.
Publicado: (2021)

Enhanced Biosynthesis of Withanolides by Elicitation and Precursor Feeding in Cell Suspension Culture of Withania somnifera (L.) Dunal in Shake-Flask Culture and Bioreactor
por: Sivanandhan, Ganeshan, et al.
Publicado: (2014)

Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease
por: Mirza, Muhammad Usman, et al.
Publicado: (2020)

The immunomodulatory role of withania somnifera (L.) dunal in inflammatory diseases
por: Alanazi, Hamad H., et al.
Publicado: (2023)

Bioassay Directed Isolation, Biological Evaluation and in Silico Studies of New Isolates from Pteris cretica L.
por: Saleem, Farooq, et al.
Publicado: (2019)

Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations
por: Rana, Satiander, et al.
Publicado: (2014)

Influence of lunar cycles on growth of Ashwagandha (Withania somnifera [L.] Dunal)
por: Tavhare, Swagata D., et al.
Publicado: (2015)

Melatonin Confers NaCl Tolerance in Withania coagulans L. by Maintaining Na(+)/K(+) Homeostasis, Strengthening the Antioxidant Defense System and Modulating Withanolides Synthesis-Related Genes
por: Dehvari-Nagan, P., et al.
Publicado: (2023)

Endophytes of Withania somnifera modulate in planta content and the site of withanolide biosynthesis
por: Pandey, Shiv S., et al.
Publicado: (2018)

Small-Intestine-Specific Delivery of Antidiabetic Extracts from Withania coagulans Using Polysaccharide-Based Enteric-Coated Nanoparticles
por: Sampathkumar, Kaarunya, et al.
Publicado: (2019)

Phytochemistry, Food Application, and Therapeutic Potential of the Medicinal Plant (Withania coagulans): A Review
por: Khan, Muhammad Issa, et al.
Publicado: (2021)

Efficacy of Ashwagandha (Withania somnifera Dunal. Linn.) in the management of psychogenic erectile dysfunction
por: Mamidi, Prasad, et al.
Publicado: (2011)

Penicillium setosum, a new species from Withania somnifera (L.) Dunal
por: George, Tijith K., et al.
Publicado: (2018)

Withania somnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID-19 Management
por: Saggam, Akash, et al.
Publicado: (2021)

An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha)
por: Bashir, Arsalan, et al.
Publicado: (2023)

In Vitro Antidiabetic, Anti-Obesity and Antioxidant Analysis of Ocimum basilicum Aerial Biomass and in Silico Molecular Docking Simulations with Alpha-Amylase and Lipase Enzymes
por: Noor, Zoy I, et al.
Publicado: (2019)

Withanolide-Type Steroids from Withania aristata as Potential Anti-Leukemic Agents
por: Moujir, Laila M., et al.
Publicado: (2020)

Identification of anti-adipogenic withanolides from the roots of Indian ginseng (Withania somnifera)
por: Lee, Seoung Rak, et al.
Publicado: (2022)

Stability indicating studies on NMITLI 118RT+ (standardized extract of withania somnifera dunal)
por: Ahmad, Hafsa, et al.
Publicado: (2014)

Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation
por: Gupta, Muskan, et al.
Publicado: (2019)

Comparative interactions of withanolides and sterols with two members of sterol glycosyltransferases from Withania somnifera
por: Pandey, Vibha, et al.
Publicado: (2015)

Evaluation of the bioavailability of major withanolides of Withania somnifera using an in vitro absorption model system
por: Devkar, Santosh T., et al.
Publicado: (2015)

Withanolides from Withania aristata as Antikinetoplastid Agents through Induction of Programmed Cell Death
por: López-Arencibia, Atteneri, et al.
Publicado: (2019)

Structural Characterization of Withanolide Glycosides from the Roots of Withania somnifera and Their Potential Biological Activities
por: Ha, Ji Won, et al.
Publicado: (2022)

Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity
por: Ahmad, Sarfraz, et al.
Publicado: (2019)

NADPH-Cytochrome P450 Reductase: Molecular Cloning and Functional Characterization of Two Paralogs from Withania somnifera (L.) Dunal
por: Rana, Satiander, et al.
Publicado: (2013)

Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults
por: Choudhary, Bakhtiar, et al.
Publicado: (2015)

Effect of Withania somnifera (L.) Dunal on Sex Hormone and Gonadotropin Levels in Addicted Male Rats
por: Rahmati, Batool, et al.
Publicado: (2016)

Changes in the leaf proteome profile of Withania somnifera (L.) Dunal in response to Alternaria alternata infection
por: Singh, Varinder, et al.
Publicado: (2017)

Critical review of the Withania somnifera (L.) Dunal: ethnobotany, pharmacological efficacy, and commercialization significance in Africa
por: Afewerky, Henok Kessete, et al.
Publicado: (2021)

Preparation, Characterization of Pregabalin and Withania coagulans Extract-Loaded Topical Gel and Their Comparative Effect on Burn Injury
por: Asghar, Anam, et al.
Publicado: (2022)

Silencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somnifera
por: Singh, Gaurav, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n5jg7ie4iv0tnsnku52vcq30b8