Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment

The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity. We investigated whether antidepressants modulate the expression of gene...

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Detalles Bibliográficos
Autores principales: Carboni, Lucia, Pischedda, Francesca, Piccoli, Giovanni, Lauria, Mario, Musazzi, Laura, Popoli, Maurizio, Mathé, Aleksander A., Domenici, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464991/
https://www.ncbi.nlm.nih.gov/pubmed/32751911
http://dx.doi.org/10.3390/cells9081818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464991/
https://www.ncbi.nlm.nih.gov/pubmed/32751911
http://dx.doi.org/10.3390/cells9081818

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