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Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment
The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity. We investigated whether antidepressants modulate the expression of gene...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464991/ https://www.ncbi.nlm.nih.gov/pubmed/32751911 http://dx.doi.org/10.3390/cells9081818 |