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PARP Inhibitor Resistance Mechanisms and Implications for Post-Progression Combination Therapies
The use of PARP inhibitors (PARPi) is growing widely as FDA approvals have shifted its use from the recurrence setting to the frontline setting. In parallel, the population developing PARPi resistance is increasing. Here we review the role of PARP, DNA damage repair, and synthetic lethality. We disc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465003/ https://www.ncbi.nlm.nih.gov/pubmed/32722408 http://dx.doi.org/10.3390/cancers12082054 |