The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges

Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the release of the nucleic acid. Moreover, protonation of histidines in the endosomes may result in endosomal swel...

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Detalles Bibliográficos
Autores principales: He, Jiaxi, Xu, Songhui, Mixson, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465012/
https://www.ncbi.nlm.nih.gov/pubmed/32823960
http://dx.doi.org/10.3390/pharmaceutics12080774

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