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Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages

The pathogenesis of psoriasis, an immune-mediated chronic skin barrier disease, is not fully understood yet. Here, we identified lysophosphatidic acid (LPA) receptor 5 (LPA(5))-mediated signaling as a novel pathogenic factor in psoriasis using an imiquimod-induced psoriasis mouse model. Amounts of m...

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Detalles Bibliográficos
Autores principales:	Gaire, Bhakta Prasad, Lee, Chi-Ho, Kim, Wondong, Sapkota, Arjun, Lee, Do Yup, Choi, Ji Woong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465035/ https://www.ncbi.nlm.nih.gov/pubmed/32707926 http://dx.doi.org/10.3390/cells9081753

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