Discovery of Sulfated Small Molecule Inhibitors of Matrix Metalloproteinase-8

Elevated matrix metalloproteinase-8 (MMP-8) activity contributes to the etiology of many diseases, including atherosclerosis, pulmonary fibrosis, and sepsis. Yet, very few small molecule inhibitors of MMP-8 have been identified. We reasoned that the synthetic non-sugar mimetics of glycosaminoglycans...

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Detalles Bibliográficos
Autores principales: Morla, Shravan, Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465109/
https://www.ncbi.nlm.nih.gov/pubmed/32784891
http://dx.doi.org/10.3390/biom10081166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465109/
https://www.ncbi.nlm.nih.gov/pubmed/32784891
http://dx.doi.org/10.3390/biom10081166

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