Cargando…
The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes. These include factors that...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465136/ https://www.ncbi.nlm.nih.gov/pubmed/32751160 http://dx.doi.org/10.3390/cancers12082106 |
_version_ | 1783577521042751488 |
---|---|
author | Boni, Jacopo Rubio-Perez, Carlota López-Bigas, Nuria Fillat, Cristina de la Luna, Susana |
author_facet | Boni, Jacopo Rubio-Perez, Carlota López-Bigas, Nuria Fillat, Cristina de la Luna, Susana |
author_sort | Boni, Jacopo |
collection | PubMed |
description | DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes. These include factors that have been associated with all the hallmarks of cancer, from genomic instability to increased proliferation and resistance, programmed cell death, or signaling pathways whose dysfunction is relevant to tumor onset and progression. In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies have been published in recent years showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression. In the present article, we will review the current understanding of the role of DYRK family members in cancer initiation and progression, providing an overview of the small molecules that act as DYRK inhibitors and discussing the clinical implications and therapeutic opportunities currently available. |
format | Online Article Text |
id | pubmed-7465136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-74651362020-09-04 The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities Boni, Jacopo Rubio-Perez, Carlota López-Bigas, Nuria Fillat, Cristina de la Luna, Susana Cancers (Basel) Review DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes. These include factors that have been associated with all the hallmarks of cancer, from genomic instability to increased proliferation and resistance, programmed cell death, or signaling pathways whose dysfunction is relevant to tumor onset and progression. In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies have been published in recent years showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression. In the present article, we will review the current understanding of the role of DYRK family members in cancer initiation and progression, providing an overview of the small molecules that act as DYRK inhibitors and discussing the clinical implications and therapeutic opportunities currently available. MDPI 2020-07-29 /pmc/articles/PMC7465136/ /pubmed/32751160 http://dx.doi.org/10.3390/cancers12082106 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boni, Jacopo Rubio-Perez, Carlota López-Bigas, Nuria Fillat, Cristina de la Luna, Susana The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title | The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title_full | The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title_fullStr | The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title_full_unstemmed | The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title_short | The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities |
title_sort | dyrk family of kinases in cancer: molecular functions and therapeutic opportunities |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465136/ https://www.ncbi.nlm.nih.gov/pubmed/32751160 http://dx.doi.org/10.3390/cancers12082106 |
work_keys_str_mv | AT bonijacopo thedyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT rubioperezcarlota thedyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT lopezbigasnuria thedyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT fillatcristina thedyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT delalunasusana thedyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT bonijacopo dyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT rubioperezcarlota dyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT lopezbigasnuria dyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT fillatcristina dyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities AT delalunasusana dyrkfamilyofkinasesincancermolecularfunctionsandtherapeuticopportunities |